24-hour activity of lisinopril: Clinical advantage in blood pressure control

We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.