24-hour activity of lisinopril: Clinical advantage in blood pressure control

A. Whelton

Research output: Contribution to journalArticle

Abstract

We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalCardiology
Volume79
DOIs
StatePublished - 1991

Fingerprint

Lisinopril
Blood Pressure
Ambulatory Blood Pressure Monitoring
Captopril
Angiotensin-Converting Enzyme Inhibitors
Multicenter Studies
Area Under Curve
Pharmacology
Hypertension
Pressure
Therapeutics

Keywords

  • 24-hour blood pressure monitoring
  • Captopril
  • Lisinopril
  • Pharmacokinetics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

24-hour activity of lisinopril : Clinical advantage in blood pressure control. / Whelton, A.

In: Cardiology, Vol. 79, 1991, p. 10-15.

Research output: Contribution to journalArticle

@article{eb04ce4fc9ac40a29fce9bf522aaac0e,
title = "24-hour activity of lisinopril: Clinical advantage in blood pressure control",
abstract = "We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.",
keywords = "24-hour blood pressure monitoring, Captopril, Lisinopril, Pharmacokinetics, Pharmacokinetics",
author = "A. Whelton",
year = "1991",
doi = "10.1159/000174901",
language = "English (US)",
volume = "79",
pages = "10--15",
journal = "Journal of Cardiovascular Medicine",
issn = "1558-2027",
publisher = "Lippincott Williams and Wilkins Ltd.",

}

TY - JOUR

T1 - 24-hour activity of lisinopril

T2 - Clinical advantage in blood pressure control

AU - Whelton, A.

PY - 1991

Y1 - 1991

N2 - We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.

AB - We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.

KW - 24-hour blood pressure monitoring

KW - Captopril

KW - Lisinopril

KW - Pharmacokinetics

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0025866090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025866090&partnerID=8YFLogxK

U2 - 10.1159/000174901

DO - 10.1159/000174901

M3 - Article

C2 - 1655261

AN - SCOPUS:0025866090

VL - 79

SP - 10

EP - 15

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

ER -