24-hour activity of lisinopril: Clinical advantage in blood pressure control

A. Whelton

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
StatePublished - 1991


  • 24-hour blood pressure monitoring
  • Captopril
  • Lisinopril
  • Pharmacokinetics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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