Abstract
We have conducted a multicentre study in patients with mild to moderate hypertension. Lisinopril monotherapy. 10. 20. or 40 mgonce daily (n=35), was compared with cap-topril monotherapy. 25, 50, or 100 mg twice daily (n = 35). Blood pressure assessments were conducted using both office and 24-hour ambulatory blood pressure monitoring. Area under the curve analysis of ambulatory blood pressure reductions demonstrated significant differences between once-daily lisinopril and twice-daily captopril. with lisinopril producing the most significant reduction in pressure. These therapeutic results reflect the clinical-pharmacological profile of these two angiotensin-converting enzyme inhibitors and provide important clinical implic.
Original language | English (US) |
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Pages (from-to) | 10-15 |
Number of pages | 6 |
Journal | Cardiology |
Volume | 79 |
DOIs | |
State | Published - 1991 |
Keywords
- 24-hour blood pressure monitoring
- Captopril
- Lisinopril
- Pharmacokinetics
- Pharmacokinetics
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology (medical)