24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma

Exposure to nitrogen dioxide (NO₂), a byproduct of combustion, is associated with poor asthma control in children. We sought to determine whether gas-fueled kitchen appliance use is associated with 24-h indoor NO₂ concentrations and whether these concentrations are associated with asthma morbidity in children. Children aged 5–12 years old with asthma were eligible. Mean 24-h NO₂ concentration was measured in the kitchen over a four-day sampling period and gas stove use was captured in time activity diaries. The relationship between stove and oven use and daily NO₂ concentration was analyzed. Longitudinal analysis assessed the effect of daily NO₂ exposure on symptoms, inhaler use, and lung function. Multivariate models were adjusted for age, sex, season, and maternal education. Thirty children contributed 126 participant days of sampling. Mean indoor 24-h NO₂ concentration was 58(48) ppb with a median (range) of 45(12–276) ppb. All homes had gas stoves and furnaces. Each hour of kitchen appliance use was associated with an 18 ppb increase in 24-h NO₂ concentration. In longitudinal multivariate analysis, each ten-fold increase in previous-day NO₂ was associated with increased nighttime inhaler use (OR = 4.9, p = 0.04). There were no associations between NO₂ and lung function or asthma symptoms. Higher previous-day 24-h concentration of NO₂ is associated with increased nighttime inhaler use in children with asthma.