22nd Symposium of the Collegium Internationale Allergologicum on From Molecular Science to the Treatment of Allergy, Corfu, Greece, September 12-16 1998: Mechanisms and pharmacologic control of basophil-derived IL-4 and IL-13

J. T. Schroeder, D. W. MacGlashan, L. M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

Human basophils represent a major source of interleukin (IL) 4 and 13 protein, cytokines which share several biological activities central to the pathogenesis of allergic inflammation. Studies show that the production of these cytokines differs with respect to mode of activation and the time course of their secretion. Pharmacologic evidence indicates that IL-4 generation, which is most prominent with IgE-dependent activation, is mediated through a calcineurin-dependent pathway. In contrast, multiple pathways seem evident in the regulation of IL-13 in basophils.

Original languageEnglish (US)
Pages (from-to)87-89
Number of pages3
JournalInternational archives of allergy and immunology
Volume118
Issue number2-4
DOIs
StatePublished - 1999

Keywords

  • Cytokines
  • FcεRI
  • IgE
  • Pharmacology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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