2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin; Min Soo Noh; Young Joo Byun; Jin Kyu Choi; Ji Young Kim; Kyung Min Lim; Jun Yong Ha; Jin Kwan Kim; Chang Hoon Lee; Shin Chung

doi:10.1016/S0960-894X(00)00634-X

2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin, Min Soo Noh, Young Joo Byun, Jin Kyu Choi, Ji Young Kim, Kyung Min Lim, Jun Yong Ha, Jin Kwan Kim, Chang Hoon Lee, Shin Chung

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00634-X
State	Published - Jan 22 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Access to Document

10.1016/S0960-894X(00)00634-X

Cite this

@article{0561c684782c40759758efcab67bcde8,

title = "2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors",

abstract = "A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).",

author = "Shin, {Song Seok} and Noh, {Min Soo} and Byun, {Young Joo} and Choi, {Jin Kyu} and Kim, {Ji Young} and Lim, {Kyung Min} and Ha, {Jun Yong} and Kim, {Jin Kwan} and Lee, {Chang Hoon} and Shin Chung",

year = "2001",

month = jan,

day = "22",

doi = "10.1016/S0960-894X(00)00634-X",

language = "English (US)",

volume = "11",

pages = "165--168",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - 2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

AU - Shin, Song Seok

AU - Noh, Min Soo

AU - Byun, Young Joo

AU - Choi, Jin Kyu

AU - Kim, Ji Young

AU - Lim, Kyung Min

AU - Ha, Jun Yong

AU - Kim, Jin Kwan

AU - Lee, Chang Hoon

AU - Chung, Shin

PY - 2001/1/22

Y1 - 2001/1/22

N2 - A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

AB - A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

UR - http://www.scopus.com/inward/record.url?scp=0035931560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035931560&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)00634-X

DO - 10.1016/S0960-894X(00)00634-X

M3 - Article

C2 - 11206450

AN - SCOPUS:0035931560

SN - 0960-894X

VL - 11

SP - 165

EP - 168

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this