2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin, Min Soo Noh, Young Joo Byun, Jin Kyu Choi, Ji Young Kim, Kyung Min Lim, Jun Yong Ha, Jin Kwan Kim, Chang Hoon Lee, Shin Chung

Research output: Contribution to journalArticle

Abstract

A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 22 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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  • Cite this

    Shin, S. S., Noh, M. S., Byun, Y. J., Choi, J. K., Kim, J. Y., Lim, K. M., Ha, J. Y., Kim, J. K., Lee, C. H., & Chung, S. (2001). 2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 11(2), 165-168. https://doi.org/10.1016/S0960-894X(00)00634-X