2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

Rohit Aggarwal, Lisa G. Rider, Nicolino Ruperto, Nastaran Bayat, Brian Erman, Brian M. Feldman, Chester V. Oddis, Anthony A. Amato, Hector Chinoy, Robert G. Cooper, Maryam Dastmalchi, David Fiorentino, David Isenberg, James D. Katz, Andrew Mammen, Marianne de Visser, Steven R. Ytterberg, Ingrid E. Lundberg, Lorinda Chung, Katalin Danko & 170 others Ignacio García-De la Torre, Yeong Wook Song, Luca Villa, Mariangela Rinaldi, Howard Rockette, Peter A. Lachenbruch, Frederick W. Miller, Jiri Vencovsky, Lisa G. Rider, Nicolino Ruperto, Rohit Aggarwal, Frederick W. Miller, Jiri Vencovsky, Rohit Aggarwal, Brian Erman, Nastaran Bayat, Angela Pistorio, Adam M. Huber, Brian M. Feldman, Paul Hansen, Howard Rockette, Peter A. Lachenbruch, Nicolino Ruperto, Lisa G. Rider, Anthony A. Amato, Hector Chinoy, Lisa Christopher-Stine, Lorinda Chung, Robert G. Cooper, Lisa Criscione-Schreiber, Leslie Crofford, Mary E. Cronin, Katalin Dankó, David Fiorentino, Ignacio García-De la Torre, Patrick Gordon, Gerald Hengstman, James D. Katz, Andrew Mammen, Galina Marder, Neil McHugh, Chester V. Oddis, Elena Schiopu, Albert Selva-O'Callaghan, Yeong Wook Song, Jiri Vencovsky, Gil Wolfe, Robert Wortmann, Anthony A. Amato, Hector Chinoy, Lorinda Chung, Robert G. Cooper, Katalin Dankó, David Fiorentino, Ignacio García-De la Torre, Mark Gourley, Ingrid Lundberg, Frederick W. Miller, Chester V. Oddis, Paul Plotz, Lisa G. Rider, Yeong Wook Song, Jiri Vencovsky, Rohit Aggarwal, Anthony A. Amato, Dana Ascherman, Richard Barohn, Olivier Benveniste, Jan De Bleecker, Jeffrey Callen, Christina Charles-Schoeman, Hector Chinoy, Lisa Christopher-Stine, Lorinda Chung, Robert G. Cooper, Leslie Crofford, Mary E. Cronin, Katalin Dankó, Sonye Danoff, Maryam Dastmalchi, Marianne de Visser, Mazen Dimachkie, Steve DiMartino, Lyubomir Dourmishev, Floranne Ernste, David Fiorentino, Ignacio García-De la Torre, Takahisa Gono, Patrick Gordon, Mark Gourley, David Isenberg, Yasuhiro Katsumata, James D. Katz, John Kissel, Richard L. Leff, Todd Levine, Ingrid Lundberg, Andrew Mammen, Herman Mann, Galina Marder, Isabelle Marie, Neil McHugh, Joseph Merola, Frederick W. Miller, Chester V. Oddis, Marzena Olesinska, Nancy Olsen, Nicolo Pipitone, Sindhu Ramchandren, Seward Rutkove, Lesley Ann Saketkoo, Adam Schiffenbauer, Albert Selva-O'Callaghan, Samuel Katsuyuki Shinjo, Rachel Shupak, Yeong Wook Song, Katarzyna Swierkocka, Jiri Vencovsky, Julia Wanschitz, Victoria Werth, Irene Whitt, Robert Wortmann, Steven R. Ytterberg, Rohit Aggarwal, Anthony A. Amato, Hector Chinoy, Lisa Christopher-Stine, Lorinda Chung, Robert G. Cooper, Mary E. Cronin, Katalin Dankó, Mazen Dimachkie, Steve DiMartino, David Fiorentino, Ignacio García-De la Torre, Patrick Gordon, Ingrid Lundberg, Herman Mann, Frederick W. Miller, Chester V. Oddis, Albert Selva-O'Callaghan, Jiri Vencovsky, Victoria Werth, Robert Wortmann, Steven R. Ytterberg, Anthony A. Amato, Hector Chinoy, Robert G. Cooper, Maryam Dastmalchi, Marianne de Visser, David Fiorentino, David Isenberg, James D. Katz, Andrew Mammen, Chester V. Oddis, Jiri Vencovsky, Steven R. Ytterberg, Rolando Cimaz, Rubén Cuttica, Sheila Knupp Feitosa de Oliveira, Brian M. Feldman, Adam M. Huber, Carol B. Lindsley, Clarissa Pilkington, Marilynn Punaro, Angelo Ravelli, Ann Reed, Kelly Rouster-Stevens, Annet van Royen-Kerkhof,

Research output: Contribution to journalArticle

Abstract

Objective: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Results: Consensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (P < 0.001). Conclusion: The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.

Original languageEnglish (US)
Pages (from-to)898-910
Number of pages13
JournalArthritis and Rheumatology
Volume69
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Myositis
Dermatomyositis
Rheumatology
Pediatrics
Clinical Trials
Physicians
Muscle Strength
Logistic Models
Regression Analysis
Muscles
Health
Enzymes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Aggarwal, R., Rider, L. G., Ruperto, N., Bayat, N., Erman, B., Feldman, B. M., ... for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation (2017). 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Arthritis and Rheumatology, 69(5), 898-910. DOI: 10.1002/art.40064

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. / Aggarwal, Rohit; Rider, Lisa G.; Ruperto, Nicolino; Bayat, Nastaran; Erman, Brian; Feldman, Brian M.; Oddis, Chester V.; Amato, Anthony A.; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; Fiorentino, David; Isenberg, David; Katz, James D.; Mammen, Andrew; de Visser, Marianne; Ytterberg, Steven R.; Lundberg, Ingrid E.; Chung, Lorinda; Danko, Katalin; García-De la Torre, Ignacio; Song, Yeong Wook; Villa, Luca; Rinaldi, Mariangela; Rockette, Howard; Lachenbruch, Peter A.; Miller, Frederick W.; Vencovsky, Jiri; Rider, Lisa G.; Ruperto, Nicolino; Aggarwal, Rohit; Miller, Frederick W.; Vencovsky, Jiri; Aggarwal, Rohit; Erman, Brian; Bayat, Nastaran; Pistorio, Angela; Huber, Adam M.; Feldman, Brian M.; Hansen, Paul; Rockette, Howard; Lachenbruch, Peter A.; Ruperto, Nicolino; Rider, Lisa G.; Amato, Anthony A.; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Criscione-Schreiber, Lisa; Crofford, Leslie; Cronin, Mary E.; Dankó, Katalin; Fiorentino, David; García-De la Torre, Ignacio; Gordon, Patrick; Hengstman, Gerald; Katz, James D.; Mammen, Andrew; Marder, Galina; McHugh, Neil; Oddis, Chester V.; Schiopu, Elena; Selva-O'Callaghan, Albert; Wook Song, Yeong; Vencovsky, Jiri; Wolfe, Gil; Wortmann, Robert; Amato, Anthony A.; Chinoy, Hector; Chung, Lorinda; Cooper, Robert G.; Dankó, Katalin; Fiorentino, David; García-De la Torre, Ignacio; Gourley, Mark; Lundberg, Ingrid; Miller, Frederick W.; Oddis, Chester V.; Plotz, Paul; Rider, Lisa G.; Wook Song, Yeong; Vencovsky, Jiri; Aggarwal, Rohit; Amato, Anthony A.; Ascherman, Dana; Barohn, Richard; Benveniste, Olivier; De Bleecker, Jan; Callen, Jeffrey; Charles-Schoeman, Christina; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Crofford, Leslie; Cronin, Mary E.; Dankó, Katalin; Danoff, Sonye; Dastmalchi, Maryam; de Visser, Marianne; Dimachkie, Mazen; DiMartino, Steve; Dourmishev, Lyubomir; Ernste, Floranne; Fiorentino, David; García-De la Torre, Ignacio; Gono, Takahisa; Gordon, Patrick; Gourley, Mark; Isenberg, David; Katsumata, Yasuhiro; Katz, James D.; Kissel, John; Leff, Richard L.; Levine, Todd; Lundberg, Ingrid; Mammen, Andrew; Mann, Herman; Marder, Galina; Marie, Isabelle; McHugh, Neil; Merola, Joseph; Miller, Frederick W.; Oddis, Chester V.; Olesinska, Marzena; Olsen, Nancy; Pipitone, Nicolo; Ramchandren, Sindhu; Rutkove, Seward; Saketkoo, Lesley Ann; Schiffenbauer, Adam; Selva-O'Callaghan, Albert; Katsuyuki Shinjo, Samuel; Shupak, Rachel; Wook Song, Yeong; Swierkocka, Katarzyna; Vencovsky, Jiri; Wanschitz, Julia; Werth, Victoria; Whitt, Irene; Wortmann, Robert; Ytterberg, Steven R.; Aggarwal, Rohit; Amato, Anthony A.; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Cronin, Mary E.; Dankó, Katalin; Dimachkie, Mazen; DiMartino, Steve; Fiorentino, David; García-De la Torre, Ignacio; Gordon, Patrick; Lundberg, Ingrid; Mann, Herman; Miller, Frederick W.; Oddis, Chester V.; Selva-O'Callaghan, Albert; Vencovsky, Jiri; Werth, Victoria; Wortmann, Robert; Ytterberg, Steven R.; Amato, Anthony A.; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; de Visser, Marianne; Fiorentino, David; Isenberg, David; Katz, James D.; Mammen, Andrew; Oddis, Chester V.; Vencovsky, Jiri; Ytterberg, Steven R.; Cimaz, Rolando; Cuttica, Rubén; Feitosa de Oliveira, Sheila Knupp; Feldman, Brian M.; Huber, Adam M.; Lindsley, Carol B.; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation.

In: Arthritis and Rheumatology, Vol. 69, No. 5, 01.05.2017, p. 898-910.

Research output: Contribution to journalArticle

Aggarwal, R, Rider, LG, Ruperto, N, Bayat, N, Erman, B, Feldman, BM, Oddis, CV, Amato, AA, Chinoy, H, Cooper, RG, Dastmalchi, M, Fiorentino, D, Isenberg, D, Katz, JD, Mammen, A, de Visser, M, Ytterberg, SR, Lundberg, IE, Chung, L, Danko, K, García-De la Torre, I, Song, YW, Villa, L, Rinaldi, M, Rockette, H, Lachenbruch, PA, Miller, FW, Vencovsky, J, Rider, LG, Ruperto, N, Aggarwal, R, Miller, FW, Vencovsky, J, Aggarwal, R, Erman, B, Bayat, N, Pistorio, A, Huber, AM, Feldman, BM, Hansen, P, Rockette, H, Lachenbruch, PA, Ruperto, N, Rider, LG, Amato, AA, Chinoy, H, Christopher-Stine, L, Chung, L, Cooper, RG, Criscione-Schreiber, L, Crofford, L, Cronin, ME, Dankó, K, Fiorentino, D, García-De la Torre, I, Gordon, P, Hengstman, G, Katz, JD, Mammen, A, Marder, G, McHugh, N, Oddis, CV, Schiopu, E, Selva-O'Callaghan, A, Wook Song, Y, Vencovsky, J, Wolfe, G, Wortmann, R, Amato, AA, Chinoy, H, Chung, L, Cooper, RG, Dankó, K, Fiorentino, D, García-De la Torre, I, Gourley, M, Lundberg, I, Miller, FW, Oddis, CV, Plotz, P, Rider, LG, Wook Song, Y, Vencovsky, J, Aggarwal, R, Amato, AA, Ascherman, D, Barohn, R, Benveniste, O, De Bleecker, J, Callen, J, Charles-Schoeman, C, Chinoy, H, Christopher-Stine, L, Chung, L, Cooper, RG, Crofford, L, Cronin, ME, Dankó, K, Danoff, S, Dastmalchi, M, de Visser, M, Dimachkie, M, DiMartino, S, Dourmishev, L, Ernste, F, Fiorentino, D, García-De la Torre, I, Gono, T, Gordon, P, Gourley, M, Isenberg, D, Katsumata, Y, Katz, JD, Kissel, J, Leff, RL, Levine, T, Lundberg, I, Mammen, A, Mann, H, Marder, G, Marie, I, McHugh, N, Merola, J, Miller, FW, Oddis, CV, Olesinska, M, Olsen, N, Pipitone, N, Ramchandren, S, Rutkove, S, Saketkoo, LA, Schiffenbauer, A, Selva-O'Callaghan, A, Katsuyuki Shinjo, S, Shupak, R, Wook Song, Y, Swierkocka, K, Vencovsky, J, Wanschitz, J, Werth, V, Whitt, I, Wortmann, R, Ytterberg, SR, Aggarwal, R, Amato, AA, Chinoy, H, Christopher-Stine, L, Chung, L, Cooper, RG, Cronin, ME, Dankó, K, Dimachkie, M, DiMartino, S, Fiorentino, D, García-De la Torre, I, Gordon, P, Lundberg, I, Mann, H, Miller, FW, Oddis, CV, Selva-O'Callaghan, A, Vencovsky, J, Werth, V, Wortmann, R, Ytterberg, SR, Amato, AA, Chinoy, H, Cooper, RG, Dastmalchi, M, de Visser, M, Fiorentino, D, Isenberg, D, Katz, JD, Mammen, A, Oddis, CV, Vencovsky, J, Ytterberg, SR, Cimaz, R, Cuttica, R, Feitosa de Oliveira, SK, Feldman, BM, Huber, AM, Lindsley, CB, Pilkington, C, Punaro, M, Ravelli, A, Reed, A, Rouster-Stevens, K, van Royen-Kerkhof, A & for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation 2017, '2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative' Arthritis and Rheumatology, vol 69, no. 5, pp. 898-910. DOI: 10.1002/art.40064

Aggarwal, Rohit; Rider, Lisa G.; Ruperto, Nicolino; Bayat, Nastaran; Erman, Brian; Feldman, Brian M.; Oddis, Chester V.; Amato, Anthony A.; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; Fiorentino, David; Isenberg, David; Katz, James D.; Mammen, Andrew; de Visser, Marianne; Ytterberg, Steven R.; Lundberg, Ingrid E.; Chung, Lorinda; Danko, Katalin; García-De la Torre, Ignacio; Song, Yeong Wook; Villa, Luca; Rinaldi, Mariangela; Rockette, Howard; Lachenbruch, Peter A.; Miller, Frederick W.; Vencovsky, Jiri; Rider, Lisa G.; Ruperto, Nicolino; Aggarwal, Rohit; Miller, Frederick W.; Vencovsky, Jiri; Aggarwal, Rohit; Erman, Brian; Bayat, Nastaran; Pistorio, Angela; Huber, Adam M.; Feldman, Brian M.; Hansen, Paul; Rockette, Howard; Lachenbruch, Peter A.; Ruperto, Nicolino; Rider, Lisa G.; Amato, Anthony A.; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Criscione-Schreiber, Lisa; Crofford, Leslie; Cronin, Mary E.; Dankó, Katalin; Fiorentino, David; García-De la Torre, Ignacio; Gordon, Patrick; Hengstman, Gerald; Katz, James D.; Mammen, Andrew; Marder, Galina; McHugh, Neil; Oddis, Chester V.; Schiopu, Elena; Selva-O'Callaghan, Albert; Wook Song, Yeong; Vencovsky, Jiri; Wolfe, Gil; Wortmann, Robert; Amato, Anthony A.; Chinoy, Hector; Chung, Lorinda; Cooper, Robert G.; Dankó, Katalin; Fiorentino, David; García-De la Torre, Ignacio; Gourley, Mark; Lundberg, Ingrid; Miller, Frederick W.; Oddis, Chester V.; Plotz, Paul; Rider, Lisa G.; Wook Song, Yeong; Vencovsky, Jiri; Aggarwal, Rohit; Amato, Anthony A.; Ascherman, Dana; Barohn, Richard; Benveniste, Olivier; De Bleecker, Jan; Callen, Jeffrey; Charles-Schoeman, Christina; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Crofford, Leslie; Cronin, Mary E.; Dankó, Katalin; Danoff, Sonye; Dastmalchi, Maryam; de Visser, Marianne; Dimachkie, Mazen; DiMartino, Steve; Dourmishev, Lyubomir; Ernste, Floranne; Fiorentino, David; García-De la Torre, Ignacio; Gono, Takahisa; Gordon, Patrick; Gourley, Mark; Isenberg, David; Katsumata, Yasuhiro; Katz, James D.; Kissel, John; Leff, Richard L.; Levine, Todd; Lundberg, Ingrid; Mammen, Andrew; Mann, Herman; Marder, Galina; Marie, Isabelle; McHugh, Neil; Merola, Joseph; Miller, Frederick W.; Oddis, Chester V.; Olesinska, Marzena; Olsen, Nancy; Pipitone, Nicolo; Ramchandren, Sindhu; Rutkove, Seward; Saketkoo, Lesley Ann; Schiffenbauer, Adam; Selva-O'Callaghan, Albert; Katsuyuki Shinjo, Samuel; Shupak, Rachel; Wook Song, Yeong; Swierkocka, Katarzyna; Vencovsky, Jiri; Wanschitz, Julia; Werth, Victoria; Whitt, Irene; Wortmann, Robert; Ytterberg, Steven R.; Aggarwal, Rohit; Amato, Anthony A.; Chinoy, Hector; Christopher-Stine, Lisa; Chung, Lorinda; Cooper, Robert G.; Cronin, Mary E.; Dankó, Katalin; Dimachkie, Mazen; DiMartino, Steve; Fiorentino, David; García-De la Torre, Ignacio; Gordon, Patrick; Lundberg, Ingrid; Mann, Herman; Miller, Frederick W.; Oddis, Chester V.; Selva-O'Callaghan, Albert; Vencovsky, Jiri; Werth, Victoria; Wortmann, Robert; Ytterberg, Steven R.; Amato, Anthony A.; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; de Visser, Marianne; Fiorentino, David; Isenberg, David; Katz, James D.; Mammen, Andrew; Oddis, Chester V.; Vencovsky, Jiri; Ytterberg, Steven R.; Cimaz, Rolando; Cuttica, Rubén; Feitosa de Oliveira, Sheila Knupp; Feldman, Brian M.; Huber, Adam M.; Lindsley, Carol B.; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation / 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

In: Arthritis and Rheumatology, Vol. 69, No. 5, 01.05.2017, p. 898-910.

Research output: Contribution to journalArticle

@article{c7ab3a9113ef4958bc9b7d4ae8a0978c,
title = "2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative",
abstract = "Objective: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Results: Consensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (P < 0.001). Conclusion: The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.",
author = "Rohit Aggarwal and Rider, {Lisa G.} and Nicolino Ruperto and Nastaran Bayat and Brian Erman and Feldman, {Brian M.} and Oddis, {Chester V.} and Amato, {Anthony A.} and Hector Chinoy and Cooper, {Robert G.} and Maryam Dastmalchi and David Fiorentino and David Isenberg and Katz, {James D.} and Andrew Mammen and {de Visser}, Marianne and Ytterberg, {Steven R.} and Lundberg, {Ingrid E.} and Lorinda Chung and Katalin Danko and {García-De la Torre}, Ignacio and Song, {Yeong Wook} and Luca Villa and Mariangela Rinaldi and Howard Rockette and Lachenbruch, {Peter A.} and Miller, {Frederick W.} and Jiri Vencovsky and Rider, {Lisa G.} and Nicolino Ruperto and Rohit Aggarwal and Miller, {Frederick W.} and Jiri Vencovsky and Rohit Aggarwal and Brian Erman and Nastaran Bayat and Angela Pistorio and Huber, {Adam M.} and Feldman, {Brian M.} and Paul Hansen and Howard Rockette and Lachenbruch, {Peter A.} and Nicolino Ruperto and Rider, {Lisa G.} and Amato, {Anthony A.} and Hector Chinoy and Lisa Christopher-Stine and Lorinda Chung and Cooper, {Robert G.} and Lisa Criscione-Schreiber and Leslie Crofford and Cronin, {Mary E.} and Katalin Dankó and David Fiorentino and {García-De la Torre}, Ignacio and Patrick Gordon and Gerald Hengstman and Katz, {James D.} and Andrew Mammen and Galina Marder and Neil McHugh and Oddis, {Chester V.} and Elena Schiopu and Albert Selva-O'Callaghan and {Wook Song}, Yeong and Jiri Vencovsky and Gil Wolfe and Robert Wortmann and Amato, {Anthony A.} and Hector Chinoy and Lorinda Chung and Cooper, {Robert G.} and Katalin Dankó and David Fiorentino and {García-De la Torre}, Ignacio and Mark Gourley and Ingrid Lundberg and Miller, {Frederick W.} and Oddis, {Chester V.} and Paul Plotz and Rider, {Lisa G.} and {Wook Song}, Yeong and Jiri Vencovsky and Rohit Aggarwal and Amato, {Anthony A.} and Dana Ascherman and Richard Barohn and Olivier Benveniste and {De Bleecker}, Jan and Jeffrey Callen and Christina Charles-Schoeman and Hector Chinoy and Lisa Christopher-Stine and Lorinda Chung and Cooper, {Robert G.} and Leslie Crofford and Cronin, {Mary E.} and Katalin Dankó and Sonye Danoff and Maryam Dastmalchi and {de Visser}, Marianne and Mazen Dimachkie and Steve DiMartino and Lyubomir Dourmishev and Floranne Ernste and David Fiorentino and {García-De la Torre}, Ignacio and Takahisa Gono and Patrick Gordon and Mark Gourley and David Isenberg and Yasuhiro Katsumata and Katz, {James D.} and John Kissel and Leff, {Richard L.} and Todd Levine and Ingrid Lundberg and Andrew Mammen and Herman Mann and Galina Marder and Isabelle Marie and Neil McHugh and Joseph Merola and Miller, {Frederick W.} and Oddis, {Chester V.} and Marzena Olesinska and Nancy Olsen and Nicolo Pipitone and Sindhu Ramchandren and Seward Rutkove and Saketkoo, {Lesley Ann} and Adam Schiffenbauer and Albert Selva-O'Callaghan and {Katsuyuki Shinjo}, Samuel and Rachel Shupak and {Wook Song}, Yeong and Katarzyna Swierkocka and Jiri Vencovsky and Julia Wanschitz and Victoria Werth and Irene Whitt and Robert Wortmann and Ytterberg, {Steven R.} and Rohit Aggarwal and Amato, {Anthony A.} and Hector Chinoy and Lisa Christopher-Stine and Lorinda Chung and Cooper, {Robert G.} and Cronin, {Mary E.} and Katalin Dankó and Mazen Dimachkie and Steve DiMartino and David Fiorentino and {García-De la Torre}, Ignacio and Patrick Gordon and Ingrid Lundberg and Herman Mann and Miller, {Frederick W.} and Oddis, {Chester V.} and Albert Selva-O'Callaghan and Jiri Vencovsky and Victoria Werth and Robert Wortmann and Ytterberg, {Steven R.} and Amato, {Anthony A.} and Hector Chinoy and Cooper, {Robert G.} and Maryam Dastmalchi and {de Visser}, Marianne and David Fiorentino and David Isenberg and Katz, {James D.} and Andrew Mammen and Oddis, {Chester V.} and Jiri Vencovsky and Ytterberg, {Steven R.} and Rolando Cimaz and Rubén Cuttica and {Feitosa de Oliveira}, {Sheila Knupp} and Feldman, {Brian M.} and Huber, {Adam M.} and Lindsley, {Carol B.} and Clarissa Pilkington and Marilynn Punaro and Angelo Ravelli and Ann Reed and Kelly Rouster-Stevens and {van Royen-Kerkhof}, Annet and {for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation}",
year = "2017",
month = "5",
doi = "10.1002/art.40064",
volume = "69",
pages = "898--910",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis

T2 - Arthritis and Rheumatology

AU - Aggarwal,Rohit

AU - Rider,Lisa G.

AU - Ruperto,Nicolino

AU - Bayat,Nastaran

AU - Erman,Brian

AU - Feldman,Brian M.

AU - Oddis,Chester V.

AU - Amato,Anthony A.

AU - Chinoy,Hector

AU - Cooper,Robert G.

AU - Dastmalchi,Maryam

AU - Fiorentino,David

AU - Isenberg,David

AU - Katz,James D.

AU - Mammen,Andrew

AU - de Visser,Marianne

AU - Ytterberg,Steven R.

AU - Lundberg,Ingrid E.

AU - Chung,Lorinda

AU - Danko,Katalin

AU - García-De la Torre,Ignacio

AU - Song,Yeong Wook

AU - Villa,Luca

AU - Rinaldi,Mariangela

AU - Rockette,Howard

AU - Lachenbruch,Peter A.

AU - Miller,Frederick W.

AU - Vencovsky,Jiri

AU - Rider,Lisa G.

AU - Ruperto,Nicolino

AU - Aggarwal,Rohit

AU - Miller,Frederick W.

AU - Vencovsky,Jiri

AU - Aggarwal,Rohit

AU - Erman,Brian

AU - Bayat,Nastaran

AU - Pistorio,Angela

AU - Huber,Adam M.

AU - Feldman,Brian M.

AU - Hansen,Paul

AU - Rockette,Howard

AU - Lachenbruch,Peter A.

AU - Ruperto,Nicolino

AU - Rider,Lisa G.

AU - Amato,Anthony A.

AU - Chinoy,Hector

AU - Christopher-Stine,Lisa

AU - Chung,Lorinda

AU - Cooper,Robert G.

AU - Criscione-Schreiber,Lisa

AU - Crofford,Leslie

AU - Cronin,Mary E.

AU - Dankó,Katalin

AU - Fiorentino,David

AU - García-De la Torre,Ignacio

AU - Gordon,Patrick

AU - Hengstman,Gerald

AU - Katz,James D.

AU - Mammen,Andrew

AU - Marder,Galina

AU - McHugh,Neil

AU - Oddis,Chester V.

AU - Schiopu,Elena

AU - Selva-O'Callaghan,Albert

AU - Wook Song,Yeong

AU - Vencovsky,Jiri

AU - Wolfe,Gil

AU - Wortmann,Robert

AU - Amato,Anthony A.

AU - Chinoy,Hector

AU - Chung,Lorinda

AU - Cooper,Robert G.

AU - Dankó,Katalin

AU - Fiorentino,David

AU - García-De la Torre,Ignacio

AU - Gourley,Mark

AU - Lundberg,Ingrid

AU - Miller,Frederick W.

AU - Oddis,Chester V.

AU - Plotz,Paul

AU - Rider,Lisa G.

AU - Wook Song,Yeong

AU - Vencovsky,Jiri

AU - Aggarwal,Rohit

AU - Amato,Anthony A.

AU - Ascherman,Dana

AU - Barohn,Richard

AU - Benveniste,Olivier

AU - De Bleecker,Jan

AU - Callen,Jeffrey

AU - Charles-Schoeman,Christina

AU - Chinoy,Hector

AU - Christopher-Stine,Lisa

AU - Chung,Lorinda

AU - Cooper,Robert G.

AU - Crofford,Leslie

AU - Cronin,Mary E.

AU - Dankó,Katalin

AU - Danoff,Sonye

AU - Dastmalchi,Maryam

AU - de Visser,Marianne

AU - Dimachkie,Mazen

AU - DiMartino,Steve

AU - Dourmishev,Lyubomir

AU - Ernste,Floranne

AU - Fiorentino,David

AU - García-De la Torre,Ignacio

AU - Gono,Takahisa

AU - Gordon,Patrick

AU - Gourley,Mark

AU - Isenberg,David

AU - Katsumata,Yasuhiro

AU - Katz,James D.

AU - Kissel,John

AU - Leff,Richard L.

AU - Levine,Todd

AU - Lundberg,Ingrid

AU - Mammen,Andrew

AU - Mann,Herman

AU - Marder,Galina

AU - Marie,Isabelle

AU - McHugh,Neil

AU - Merola,Joseph

AU - Miller,Frederick W.

AU - Oddis,Chester V.

AU - Olesinska,Marzena

AU - Olsen,Nancy

AU - Pipitone,Nicolo

AU - Ramchandren,Sindhu

AU - Rutkove,Seward

AU - Saketkoo,Lesley Ann

AU - Schiffenbauer,Adam

AU - Selva-O'Callaghan,Albert

AU - Katsuyuki Shinjo,Samuel

AU - Shupak,Rachel

AU - Wook Song,Yeong

AU - Swierkocka,Katarzyna

AU - Vencovsky,Jiri

AU - Wanschitz,Julia

AU - Werth,Victoria

AU - Whitt,Irene

AU - Wortmann,Robert

AU - Ytterberg,Steven R.

AU - Aggarwal,Rohit

AU - Amato,Anthony A.

AU - Chinoy,Hector

AU - Christopher-Stine,Lisa

AU - Chung,Lorinda

AU - Cooper,Robert G.

AU - Cronin,Mary E.

AU - Dankó,Katalin

AU - Dimachkie,Mazen

AU - DiMartino,Steve

AU - Fiorentino,David

AU - García-De la Torre,Ignacio

AU - Gordon,Patrick

AU - Lundberg,Ingrid

AU - Mann,Herman

AU - Miller,Frederick W.

AU - Oddis,Chester V.

AU - Selva-O'Callaghan,Albert

AU - Vencovsky,Jiri

AU - Werth,Victoria

AU - Wortmann,Robert

AU - Ytterberg,Steven R.

AU - Amato,Anthony A.

AU - Chinoy,Hector

AU - Cooper,Robert G.

AU - Dastmalchi,Maryam

AU - de Visser,Marianne

AU - Fiorentino,David

AU - Isenberg,David

AU - Katz,James D.

AU - Mammen,Andrew

AU - Oddis,Chester V.

AU - Vencovsky,Jiri

AU - Ytterberg,Steven R.

AU - Cimaz,Rolando

AU - Cuttica,Rubén

AU - Feitosa de Oliveira,Sheila Knupp

AU - Feldman,Brian M.

AU - Huber,Adam M.

AU - Lindsley,Carol B.

AU - Pilkington,Clarissa

AU - Punaro,Marilynn

AU - Ravelli,Angelo

AU - Reed,Ann

AU - Rouster-Stevens,Kelly

AU - van Royen-Kerkhof,Annet

AU - for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Results: Consensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (P < 0.001). Conclusion: The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.

AB - Objective: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Results: Consensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (P < 0.001). Conclusion: The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.

UR - http://www.scopus.com/inward/record.url?scp=85017448052&partnerID=8YFLogxK

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U2 - 10.1002/art.40064

DO - 10.1002/art.40064

M3 - Article

VL - 69

SP - 898

EP - 910

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 5

ER -