2-[18F]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors

Andrew G. Horti, Ursula Scheffel, Andrei O. Koren, Hayden T. Ravert, William B. Mathews, John L. Musachio, Paige A. Finley, Edythe D. London, Robert F. Dannals

Research output: Contribution to journalArticle

Abstract

The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAChR selective ligands as well as with unlabeled 2-fluoro-A-85380. A preliminary toxicology study of the 2-fluoro- A-85380 showed a relatively low biological effect. 2-[18F]Fluoro-A-85380 holds promise as a useful radiotracer for imaging of nAChRs with PET.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalNuclear Medicine and Biology
Volume25
Issue number7
DOIs
StatePublished - Oct 1 1998

Keywords

  • A-85380 derivative
  • Acetylcholine receptor
  • Brain distribution
  • Nicotinic receptor
  • PET
  • Pharmacology
  • Radiotracer

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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