2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver

Dipali Sharma; S. Radhika; K. Muralidhar; Aparna Dixit

doi:10.1016/0304-3835(95)03810-J

2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver

Dipali Sharma, S. Radhika, K. Muralidhar, Aparna Dixit

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	Cancer Letters
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(95)03810-J
State	Published - Jul 13 1995
Externally published	Yes

Keywords

MPG
Regenerating liver
c-Ha-ras
c-jun

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(95)03810-J

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title = "2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver",

abstract = "Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.",

keywords = "MPG, Regenerating liver, c-Ha-ras, c-jun",

author = "Dipali Sharma and S. Radhika and K. Muralidhar and Aparna Dixit",

note = "Funding Information: This work has been supportedb y a research grant( #37( 834)/94-EMR-II)f rom the Council of Scientifica nd Industrial Research( CSIR), India, to A.D. CSIR, India, is also acknowledgefdo r the JRF awardt o S.R. The authorsa reg ratefult o Mr. R.K. Bhandarif or the line diagrams.",

year = "1995",

month = jul,

day = "13",

doi = "10.1016/0304-3835(95)03810-J",

language = "English (US)",

volume = "93",

pages = "201--205",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - 2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver

AU - Sharma, Dipali

AU - Radhika, S.

AU - Muralidhar, K.

AU - Dixit, Aparna

N1 - Funding Information: This work has been supportedb y a research grant( #37( 834)/94-EMR-II)f rom the Council of Scientifica nd Industrial Research( CSIR), India, to A.D. CSIR, India, is also acknowledgefdo r the JRF awardt o S.R. The authorsa reg ratefult o Mr. R.K. Bhandarif or the line diagrams.

PY - 1995/7/13

Y1 - 1995/7/13

N2 - Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.

AB - Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.

KW - MPG

KW - Regenerating liver

KW - c-Ha-ras

KW - c-jun

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AN - SCOPUS:0029045336

SN - 0304-3835

VL - 93

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JF - Cancer Letters

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ER -

2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver

Abstract

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