2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver

Dipali Sharma, S. Radhika, K. Muralidhar, Aparna Dixit

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalCancer Letters
Volume93
Issue number2
DOIs
StatePublished - Jul 13 1995

Keywords

  • MPG
  • Regenerating liver
  • c-Ha-ras
  • c-jun

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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