2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir

F. M. Hamzeh, T. Spector, P. S. Lietman

Research output: Contribution to journalComment/debatepeer-review

Abstract

We studied the effects of 2-acetylpyridine 5- [(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells. We show that 1110U81 is a potent inhibitor of HCMV DNA replication (50% inhibitory concentration [IC50], 3.6 μM; IC90, 5.6 μM) and also potentiates the effects of ganciclovir (GCV) against HCMV. The IC90 of GCV is reduced from 65 μM when GCV alone is given to 2.8 μM when GCV is combined with 1110U81 at a molar ratio of 1:1.

Original languageEnglish (US)
Pages (from-to)602-604
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume37
Issue number3
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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