The novel 3-modified 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3] analogues 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate are synthesized from L-quebrachitol, and the preliminary results on their Ca 2+ releasing activity suggest that the Ins(1,4,5)P3 receptor can accommodate some steric bulk in the axial region of the 3-position of Ins(1,4,5)P3 when the equatorial 3-hydroxy group is retained.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1994|
ASJC Scopus subject areas
- Molecular Medicine