TY - JOUR
T1 - 18F‐2‐deoxy‐2‐fluoro‐D‐glucose uptake into human tumor xenografts. Feasibility studies for cancer imaging with positron‐emission tomography
AU - Wahl, Richard L.
AU - Hutchins, Gary D.
AU - Buchsbaum, Donald J.
AU - Liebert, Monica
AU - Grossman, H. Barton
AU - Fisher, Susan
PY - 1991/3/15
Y1 - 1991/3/15
N2 - The positron‐emitting glucose analogue 18F‐2‐fluoro‐2‐deoxy‐d‐glucose (FDG) was evaluated for its accretion into the following subcutaneous human tumor xenografts in nude mice: B‐cell lymphoma (Namalwa or Raji), ovarian carcinoma (HTB77), colon cancer (SW948), choriocarcinoma (BEWO), bladder cancer (UM‐UC‐2), renal cell carcinoma (UM‐RC‐3), neuroblastoma (Mey), melanoma (HTB63), and small cell lung carcinoma (NCI69). Two hours postinjection, tumor uptakes ranged from 0.027 (colon cancer) to 0.125% kg injected dose/g (melanoma); and was greater than 0.085 in the Namalwa lymphomas and the renal cell carcinomas. Tumor‐blood ratios of up to 23:1 were seen 2 hours postinjection (melanoma) with a mean tumor‐blood ratio for all tumors of 12.3 ± 1.8. Uptake in the other tumors was intermediate. When evaluated, tumor uptake was slightly greater at 1 than at 2 hours postinjection, although target‐background ratios were generally higher at 2 hours postinjection. This compound, FDG, may have broad applicability as a tracer for positron‐emission tomographic imaging of many human malignancies.
AB - The positron‐emitting glucose analogue 18F‐2‐fluoro‐2‐deoxy‐d‐glucose (FDG) was evaluated for its accretion into the following subcutaneous human tumor xenografts in nude mice: B‐cell lymphoma (Namalwa or Raji), ovarian carcinoma (HTB77), colon cancer (SW948), choriocarcinoma (BEWO), bladder cancer (UM‐UC‐2), renal cell carcinoma (UM‐RC‐3), neuroblastoma (Mey), melanoma (HTB63), and small cell lung carcinoma (NCI69). Two hours postinjection, tumor uptakes ranged from 0.027 (colon cancer) to 0.125% kg injected dose/g (melanoma); and was greater than 0.085 in the Namalwa lymphomas and the renal cell carcinomas. Tumor‐blood ratios of up to 23:1 were seen 2 hours postinjection (melanoma) with a mean tumor‐blood ratio for all tumors of 12.3 ± 1.8. Uptake in the other tumors was intermediate. When evaluated, tumor uptake was slightly greater at 1 than at 2 hours postinjection, although target‐background ratios were generally higher at 2 hours postinjection. This compound, FDG, may have broad applicability as a tracer for positron‐emission tomographic imaging of many human malignancies.
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U2 - 10.1002/1097-0142(19910315)67:6<1544::AID-CNCR2820670614>3.0.CO;2-0
DO - 10.1002/1097-0142(19910315)67:6<1544::AID-CNCR2820670614>3.0.CO;2-0
M3 - Article
C2 - 2001543
AN - SCOPUS:0025810148
SN - 0008-543X
VL - 67
SP - 1544
EP - 1550
JO - Cancer
JF - Cancer
IS - 6
ER -