17β-estradiol increases Leishmania mexicana killing in macrophages from DBA/2 mice by enhancing production of nitric oxide but not pro-inflammatory cytokines

C. M. Lezama-Dávila, A. P. Isaac-Márquez, J. Barbi, S. Oghumu, A. R. Satoskar

Research output: Contribution to journalArticle

Abstract

We have previously shown that female DBA/2 mice are significantly more resistant to Leishmania mexicana compared with males. Here, we have analyzed the effect of 17β-estradiol (E2) on function and cytokine production in male and female DBA/2 macrophages in vitro. We show that E 2 increases NO production and parasite killing in L. mexicana-infected male and female DBA/2 macrophages without increasing production of pro-inflammatory cytokines. These data indicate that E2 may enhance leishmanicidal activity in macrophages by directly regulating production of NO.

Original languageEnglish (US)
Pages (from-to)1125-1127
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number6
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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