17α-hydroxyprogesterone caproate for the prevention of preterm delivery: A cost-effectiveness analysis

Anthony O. Odibo, David M. Stamilio, George A. Macones, Daniel Polsky

Research output: Contribution to journalArticle

Abstract

To evaluate whether the use of 17α-hydroxyprogesterone caproate for the prevention of recurrent preterm deliveries is cost-effective. Using decision-analysis modeling, we compared the cost-effectiveness of using 17α-hydroxyprogesterone caproate in four subgroups: 1) Prior preterm deliveries less than 32 weeks; 2) prior preterm deliveries 32-37 weeks; 3) prior term delivery; and 4) no prior delivery. Each subgroup was compared with a “no treatment” group. Costs included those for 17α-hydroxyprogesterone caproate, hospital admissions, and complications from preterm deliveries. The main outcome measures include cost per quality-adjusted life-year gained and the number of preterm deliveries prevented. Secondary outcomes include neonatal complications prevented. One-way and multiway sensitivity analyses were performed. The use of 17α-hydroxyprogesterone caproate for the prevention of preterm deliveries result in cost-savings in women with prior preterm deliveries less than 32 weeks and 32-37 weeks. The sensitivity analyses revealed the model to be robust over a wide range of values for evaluated variables. Within our baseline assumptions, 17α-hydroxyprogesterone caproate was associated with cost-savings when used for the prevention of preterm deliveries in women with prior preterm deliveries. II-3.

Original languageEnglish (US)
Pages (from-to)492-499
Number of pages8
JournalObstetrics and gynecology
Volume108
Issue number3
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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