15-year experience with rotavirus vaccination in Mexico: a systematic literature review

Adriana Guzman-Holst, Eduardo Ortega-Barria, Ángel Alexis Flores, Roberto Carreño-Manjarrez, Dagna Constenla, Maria Yolanda Cervantes-Apolinar

Research output: Contribution to journalReview articlepeer-review


A systematic review was conducted in Mexico to consolidate and evaluate evidence after 15 years of rotavirus vaccination, according to the National Immunization Program. Five databases were screened to identify published articles (January 2000–February 2020) with evidence on all clinical and epidemiological endpoints (e.g. immunogenicity, safety, efficacy, impact/effectiveness) of rotavirus vaccination in Mexico. Twenty-two articles were identified (observational studies including health-economic models: 17; randomized controlled trials: 5). Fourteen studies evaluated a human attenuated vaccine (HRV), four studies evaluated both vaccines, and only two evaluated a bovine-human reassortant vaccine, with local efficacy data only for HRV. Local evidence shows vaccines are safe, immunogenic, efficacious, and provide an acceptable risk-benefit profile. The benefits of both vaccines in alleviating the burden of all-cause diarrhea mortality and morbidity are documented in several local post-licensure studies. Findings signify overall benefits of rotavirus vaccination and support the continued use of rotavirus vaccine in Mexico.

Original languageEnglish (US)
Pages (from-to)3623-3637
Number of pages15
JournalHuman Vaccines and Immunotherapeutics
Issue number10
StatePublished - 2021
Externally publishedYes


  • Mexico
  • acute diarrhea
  • disease burden
  • health economics
  • immunogenicity
  • intussusception
  • rotavirus gastroenteritis
  • rotavirus vaccine
  • systematic review

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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