15-lipoxygenase in glomerular inflammation

Angel Montero, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

Glomerulonephritis is a significant factor fueling the rapid increase in the population of patients with end-stage renal disease. Novel therapeutic strategies targeting specific mechanisms of glomerular destruction are the most reasonable approaches to arrest ongoing injury. In this review, we summarize some of our results obtained in our effort to characterize the role of 15-lipoxygenase activation as one of the mechansisms operative during the early, prefibrotic stage of glomerular immune injury. We also summarize the effects of cytokines released during these processes, as well as the activation by aspirin of the synthesis of 15-R-HETE (see text). Finally, we will propose a clinical approach to this group of disorders, based on emerging concepts of the pathophysiology of glomerulonephritis from our work and that of several other investigators.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalExperimental Nephrology
Volume8
Issue number1
StatePublished - Jan 2000
Externally publishedYes

Fingerprint

Arachidonate 15-Lipoxygenase
Glomerulonephritis
Inflammation
Wounds and Injuries
Aspirin
Chronic Kidney Failure
Research Personnel
Cytokines
Population
Therapeutics
15-hydroxy-5,8,11,13-eicosatetraenoic acid

Keywords

  • Arachidonic acid
  • Glomerulonephritis
  • Lipoxins

ASJC Scopus subject areas

  • Nephrology

Cite this

Montero, A., & Badr, K. F. (2000). 15-lipoxygenase in glomerular inflammation. Experimental Nephrology, 8(1), 14-19.

15-lipoxygenase in glomerular inflammation. / Montero, Angel; Badr, Kamal F.

In: Experimental Nephrology, Vol. 8, No. 1, 01.2000, p. 14-19.

Research output: Contribution to journalArticle

Montero, A & Badr, KF 2000, '15-lipoxygenase in glomerular inflammation', Experimental Nephrology, vol. 8, no. 1, pp. 14-19.
Montero A, Badr KF. 15-lipoxygenase in glomerular inflammation. Experimental Nephrology. 2000 Jan;8(1):14-19.
Montero, Angel ; Badr, Kamal F. / 15-lipoxygenase in glomerular inflammation. In: Experimental Nephrology. 2000 ; Vol. 8, No. 1. pp. 14-19.
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