15-lipoxygenase in glomerular inflammation

Angel Montero, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

Glomerulonephritis is a significant factor fueling the rapid increase in the population of patients with end-stage renal disease. Novel therapeutic strategies targeting specific mechanisms of glomerular destruction are the most reasonable approaches to arrest ongoing injury. In this review, we summarize some of our results obtained in our effort to characterize the role of 15-lipoxygenase activation as one of the mechansisms operative during the early, prefibrotic stage of glomerular immune injury. We also summarize the effects of cytokines released during these processes, as well as the activation by aspirin of the synthesis of 15-R-HETE (see text). Finally, we will propose a clinical approach to this group of disorders, based on emerging concepts of the pathophysiology of glomerulonephritis from our work and that of several other investigators.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalExperimental Nephrology
Volume8
Issue number1
Publication statusPublished - Jan 2000
Externally publishedYes

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Keywords

  • Arachidonic acid
  • Glomerulonephritis
  • Lipoxins

ASJC Scopus subject areas

  • Nephrology

Cite this

Montero, A., & Badr, K. F. (2000). 15-lipoxygenase in glomerular inflammation. Experimental Nephrology, 8(1), 14-19.