TY - JOUR
T1 - 14-3-3 proteins
T2 - regulation of endoplasmic reticulum localization and surface expression of membrane proteins
AU - Shikano, Sojin
AU - Coblitz, Brian
AU - Wu, Meng
AU - Li, Min
N1 - Funding Information:
We thank Steve Goldstein and Blanche Schwappach for discussion and sharing unpublished results, and members of the Li laboratory for valuable comments on this manuscript. This work is supported by a grant from the National Institutes of Health (to M.L.GM70959) and a pre-doctoral training award (B.C.) from the American Heart Association.
PY - 2006/7
Y1 - 2006/7
N2 - The density and composition of cell surface proteins are major determinants for cellular functions. Regulation of cell surface molecules occurs at several levels, including the efficiency of surface transport, and is therefore of great interest. As the major phosphoprotein-binding modules, 14-3-3 proteins are known for their crucial roles in a wide range of cellular activities, including the subcellular localization of target proteins. Accumulating evidence suggests a role for 14-3-3 in surface transport of membrane proteins, in which 14-3-3 binding reduces endoplasmic reticulum (ER) localization, thereby promoting surface expression of membrane proteins. Here, we focus on recent evidence of 14-3-3-mediated surface transport and discuss the possible molecular mechanisms.
AB - The density and composition of cell surface proteins are major determinants for cellular functions. Regulation of cell surface molecules occurs at several levels, including the efficiency of surface transport, and is therefore of great interest. As the major phosphoprotein-binding modules, 14-3-3 proteins are known for their crucial roles in a wide range of cellular activities, including the subcellular localization of target proteins. Accumulating evidence suggests a role for 14-3-3 in surface transport of membrane proteins, in which 14-3-3 binding reduces endoplasmic reticulum (ER) localization, thereby promoting surface expression of membrane proteins. Here, we focus on recent evidence of 14-3-3-mediated surface transport and discuss the possible molecular mechanisms.
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U2 - 10.1016/j.tcb.2006.05.006
DO - 10.1016/j.tcb.2006.05.006
M3 - Review article
C2 - 16769213
AN - SCOPUS:33745949394
VL - 16
SP - 370
EP - 375
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 7
ER -