14-3-3, an integrator of cell mechanics and cytokinesis

Research output: Contribution to journalArticle

Abstract

One of the goals of understanding cytokinesis is to uncover the molecular regulation of the cellular mechanical properties that drive cell shape change. Such regulatory pathways are likely to be used at multiple stages of a cell's life, but are highly featured during cell division. Recently, we demonstrated that 14-3-3 (encoded by a single gene in the social amoeba Dictyostelium discoideum) serves to integrate key cytoskeletal components- microtubules, Rac and myosin II-to control cell mechanics and cytokinesis. As 14-3-3 proteins are frequently altered in a variety of human tumors, we extend these observations to suggest possible additional roles for how 14-3-3 proteins may contribute to tumorigenesis.

Original languageEnglish (US)
JournalSmall GTPases
Volume1
Issue number3
StatePublished - Nov 2010

Fingerprint

14-3-3 Proteins
Cytokinesis
Mechanics
Myosin Type II
Amoeba
Dictyostelium
Cell Shape
Microtubules
Cell Division
Tumors
Carcinogenesis
Genes
Cells
Mechanical properties
Neoplasms

Keywords

  • 14-3-3
  • Bipolar thick filament
  • Cancer
  • Cell mechanics
  • Cortical tension
  • Cytokinesis
  • Microtubules
  • Myosin II
  • Rac
  • Tumor suppressor
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

14-3-3, an integrator of cell mechanics and cytokinesis. / Robinson, Douglas.

In: Small GTPases, Vol. 1, No. 3, 11.2010.

Research output: Contribution to journalArticle

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