14-3-3, an integrator of cell mechanics and cytokinesis

Research output: Contribution to journalArticlepeer-review

Abstract

One of the goals of understanding cytokinesis is to uncover the molecular regulation of the cellular mechanical properties that drive cell shape change. Such regulatory pathways are likely to be used at multiple stages of a cell's life, but are highly featured during cell division. Recently, we demonstrated that 14-3-3 (encoded by a single gene in the social amoeba Dictyostelium discoideum) serves to integrate key cytoskeletal components- microtubules, Rac and myosin II-to control cell mechanics and cytokinesis. As 14-3-3 proteins are frequently altered in a variety of human tumors, we extend these observations to suggest possible additional roles for how 14-3-3 proteins may contribute to tumorigenesis.

Original languageEnglish (US)
JournalSmall GTPases
Volume1
Issue number3
DOIs
StatePublished - 2010

Keywords

  • 14-3-3
  • Bipolar thick filament
  • Cancer
  • Cell mechanics
  • Cortical tension
  • Cytokinesis
  • Microtubules
  • Myosin II
  • Rac
  • Tumor suppressor
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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