13-cis-retinoic acid: Inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

Clinton J. Grubbs, Richard C. Moon, Robert A. Squire, George M. Farrow, Sherman F. Stinson, Dawn G. Goodman, Charles C. Brown, Michael B. Sporn

Research output: Contribution to journalArticle

Abstract

Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.

Original languageEnglish (US)
Pages (from-to)743-744
Number of pages2
JournalScience
Volume198
Issue number4318
DOIs
StatePublished - Jan 1 1977

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    Grubbs, C. J., Moon, R. C., Squire, R. A., Farrow, G. M., Stinson, S. F., Goodman, D. G., Brown, C. C., & Sporn, M. B. (1977). 13-cis-retinoic acid: Inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. Science, 198(4318), 743-744. https://doi.org/10.1126/science.910158