1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls

Research output: Contribution to journalArticle

Abstract

Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required.

Original languageEnglish (US)
Pages (from-to)20-24
Number of pages5
JournalJournal of Neuroimmunology
Volume279
Issue numberC
DOIs
StatePublished - Jan 1 2015

Keywords

  • Immunological memory
  • Multiple sclerosis
  • T cell
  • Vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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