TY - JOUR
T1 - 11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans
AU - Ordonez, Alvaro A.
AU - Parker, Matthew F.L.
AU - Miller, Robert J.
AU - Plyku, Donika
AU - Ruiz-Bedoya, Camilo A.
AU - Tucker, Elizabeth W.
AU - Luu, Justin M.
AU - Dikeman, Dustin A.
AU - Lesniak, Wojciech G.
AU - Holt, Daniel P.
AU - Dannals, Robert F.
AU - Miller, Lloyd S.
AU - Rowe, Steven P.
AU - Wilson, David M.
AU - Jain, Sanjay K.
N1 - Publisher Copyright:
© 2022, Ordonez et al.
PY - 2022/1/11
Y1 - 2022/1/11
N2 - Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the development of related PET radiotracers. In this study, 11C-PABA PET imaging was used to accurately detect and monitor infections due to pyogenic bacteria in multiple clinically relevant animal models. 11C-PABA PET imaging selectively detected infections in muscle, intervertebral discs, and methicillin-resistant Staphylococcus aureus-infected orthopedic implants. In what we believe to be first-in-human studies in healthy participants, 11C-PABA was safe, well-tolerated, and had a favorable biodistribution, with low background activity in the lungs, muscles, and brain. 11C-PABA has the potential for clinical translation to detect and localize a broad range of bacteria.
AB - Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the development of related PET radiotracers. In this study, 11C-PABA PET imaging was used to accurately detect and monitor infections due to pyogenic bacteria in multiple clinically relevant animal models. 11C-PABA PET imaging selectively detected infections in muscle, intervertebral discs, and methicillin-resistant Staphylococcus aureus-infected orthopedic implants. In what we believe to be first-in-human studies in healthy participants, 11C-PABA was safe, well-tolerated, and had a favorable biodistribution, with low background activity in the lungs, muscles, and brain. 11C-PABA has the potential for clinical translation to detect and localize a broad range of bacteria.
UR - http://www.scopus.com/inward/record.url?scp=85123106175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123106175&partnerID=8YFLogxK
U2 - 10.1172/jci.insight.154117
DO - 10.1172/jci.insight.154117
M3 - Article
C2 - 35014627
AN - SCOPUS:85123106175
SN - 2379-3708
VL - 7
JO - JCI Insight
JF - JCI Insight
IS - 1
M1 - e154117
ER -