1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D2 receptor hypersensitivity in the mouse is transient

S. J. Peroutka, L. DeLanney, I. Irwin, P. J. Ison, G. Ricaurte, J. R. Schlegel, J. W. Langston

Research output: Contribution to journalArticle

Abstract

Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour x 4 schedule, the number of dopamine D2 receptors labeled by 3H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 ± 8.0% of control values; p < 0.025). Scatchard analysis revealed an increase in the number of 3H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in 3H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day x 10 MPTP caused a transient increase in 3H-spiperone binding to dopamine D2 receptor (1 day: 143 ± 12%, p < 0.01; 10 days: 101 ± 3.7%, p > 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D2 reeptors in the mnouse.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume48
Issue number2
StatePublished - Oct 16 1985

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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