1. Information role of fibrinogen content in functioning of fibrinolysis and haemostasis

G. V. Andreenko, L. V. Podorolskaja, K. A. Nikolskaja, A. V. Savonenko, T. N. Serebrjakova

Research output: Contribution to journalArticle

Abstract

Penetration of dynamical chaos concepts into medical science has an important role in the development of our ideas about the pathology state of the organism. It was shown that emergence of pathology situation was a result of the loss of chaos properties by physiological system, that led to a sharp decrease of essential population parameter - 'norm of reaction' (Ary et al 1987). The distribution curves of indices of fibrinolysis and haemostasis in a population of normal Wistar rats (n=120) were studied. Among the variety of routine indices, Fb concentration was the single factor that had the smallest range - 'norm of reaction' (Kvar=27.1 %). Fb content was extremely stable as to activity of fibrinolysis and to functional state of each studied fibrinolytic and haemostatic indices. At the same time, Fb demonstrated the highest sensitivity to pathological factorethanol consumption: higher the ethanol consumption, the nearer was the average Fb level (4.9 1.3 g/1) to upper threshold value of norm of reaction (from 4.5 to 5.6 g/1, and its range of data became smaller (44.6%). The obtained data permit to ascribe Fb to regulatory parameter, reflecting the stability of the fibrinolytic and haemostatic system. The prognostic significance of Fb may be expanded, if one takes into account its norm of reaction.

Original languageEnglish (US)
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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