1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

Alan P. Kozikowski, Gian Luca Araldi, Werner Tückmantel, Sergey Pshenichkin, Elena Surina, Jarda T. Wroblewski

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.

Original languageEnglish (US)
Pages (from-to)1721-1726
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number12
DOIs
StatePublished - Jun 21 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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