1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALCÆMIA OF SARCOIDOSIS

S. E. Papapoulos; L. J. Fraher; L. M. Sandler; T. L. Clemens; I. G. Lewin; J. L.H. O'Riordan

doi:10.1016/S0140-6736(79)91076-6

1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALCÆMIA OF SARCOIDOSIS

S. E. Papapoulos, L. J. Fraher, L. M. Sandler, T. L. Clemens, I. G. Lewin, J. L.H. O'Riordan

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Abstract

A 36-year-old man with sarcoidosis had four episodes of hypercalcæmia in seven years, all of them during the summer months. Measurement over three years showed that hypercalcæmia was associated with small seasonal increases in serum-25-hydroxycholecalciferol within the normal range. These changes could be mimicked by the administration of 3000 units of vitamin D₃ daily. Serum 1, 25-dihydroxy-cholecalciferol concentrations ranged between 26-62 pg/ml when serum calcium was normal, but were strikingly high, up to 137 pg/ml, when the patient was hypercalcæmic. These studies show for the first time that hypercalcæmia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D.

Original language	English (US)
Pages (from-to)	627-630
Number of pages	4
Journal	The Lancet
Volume	313
Issue number	8117
DOIs	https://doi.org/10.1016/S0140-6736(79)91076-6
State	Published - Mar 24 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALC{\AE}MIA OF SARCOIDOSIS",

abstract = "A 36-year-old man with sarcoidosis had four episodes of hypercalc{\ae}mia in seven years, all of them during the summer months. Measurement over three years showed that hypercalc{\ae}mia was associated with small seasonal increases in serum-25-hydroxycholecalciferol within the normal range. These changes could be mimicked by the administration of 3000 units of vitamin D3 daily. Serum 1, 25-dihydroxy-cholecalciferol concentrations ranged between 26-62 pg/ml when serum calcium was normal, but were strikingly high, up to 137 pg/ml, when the patient was hypercalc{\ae}mic. These studies show for the first time that hypercalc{\ae}mia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D.",

author = "Papapoulos, {S. E.} and Fraher, {L. J.} and Sandler, {L. M.} and Clemens, {T. L.} and Lewin, {I. G.} and O'Riordan, {J. L.H.}",

note = "Funding Information: the patient and The Wellcome Trust for financial support.",

year = "1979",

month = mar,

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doi = "10.1016/S0140-6736(79)91076-6",

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pages = "627--630",

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AU - Papapoulos, S. E.

AU - Fraher, L. J.

AU - Sandler, L. M.

AU - Clemens, T. L.

AU - Lewin, I. G.

AU - O'Riordan, J. L.H.

N1 - Funding Information: the patient and The Wellcome Trust for financial support.

PY - 1979/3/24

Y1 - 1979/3/24

N2 - A 36-year-old man with sarcoidosis had four episodes of hypercalcæmia in seven years, all of them during the summer months. Measurement over three years showed that hypercalcæmia was associated with small seasonal increases in serum-25-hydroxycholecalciferol within the normal range. These changes could be mimicked by the administration of 3000 units of vitamin D3 daily. Serum 1, 25-dihydroxy-cholecalciferol concentrations ranged between 26-62 pg/ml when serum calcium was normal, but were strikingly high, up to 137 pg/ml, when the patient was hypercalcæmic. These studies show for the first time that hypercalcæmia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D.

AB - A 36-year-old man with sarcoidosis had four episodes of hypercalcæmia in seven years, all of them during the summer months. Measurement over three years showed that hypercalcæmia was associated with small seasonal increases in serum-25-hydroxycholecalciferol within the normal range. These changes could be mimicked by the administration of 3000 units of vitamin D3 daily. Serum 1, 25-dihydroxy-cholecalciferol concentrations ranged between 26-62 pg/ml when serum calcium was normal, but were strikingly high, up to 137 pg/ml, when the patient was hypercalcæmic. These studies show for the first time that hypercalcæmia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D.

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1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALCÆMIA OF SARCOIDOSIS

Abstract

ASJC Scopus subject areas

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