1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II

Gary H. Posner, Jae Kyoo Lee, Zhengong Li, Kazuhiro Takeuchi, Sandra E. Guggino, Patrick Dolan, Thomas W. Kensler

Research output: Contribution to journalArticle

Abstract

Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (±)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.

Original languageEnglish (US)
Pages (from-to)2163-2168
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number18
DOIs
StatePublished - Sep 21 1995

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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