1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II

Gary H. Posner; Jae Kyoo Lee; Zhengong Li; Kazuhiro Takeuchi; Sandra E. Guggino; Patrick Dolan; Thomas W. Kensler

doi:10.1016/0960-894X(95)00376-5

1α,25-Dihydroxyvitamin D₃ Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II

Gary H. Posner, Jae Kyoo Lee, Zhengong Li, Kazuhiro Takeuchi, Sandra E. Guggino, Patrick Dolan, Thomas W. Kensler

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (±)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.

Original language	English (US)
Pages (from-to)	2163-2168
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	18
DOIs	https://doi.org/10.1016/0960-894X(95)00376-5
State	Published - Sep 21 1995

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(95)00376-5

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abstract = "Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (±)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.",

author = "Posner, {Gary H.} and Lee, {Jae Kyoo} and Zhengong Li and Kazuhiro Takeuchi and Guggino, {Sandra E.} and Patrick Dolan and Kensler, {Thomas W.}",

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AU - Posner, Gary H.

AU - Lee, Jae Kyoo

AU - Li, Zhengong

AU - Takeuchi, Kazuhiro

AU - Guggino, Sandra E.

AU - Dolan, Patrick

AU - Kensler, Thomas W.

PY - 1995/9/21

Y1 - 1995/9/21

N2 - Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (±)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.

AB - Calcitriol analogs 3 and 4, prepared by convergent coupling of 1-hydroxymethyl A-ring phosphine oxide (±)-5 and structurally modified C,D-ring ketones (-)-6, are shown to be hybrid analogs with blended and potent, but variable, biological activities.

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1α,25-Dihydroxyvitamin D₃ Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II

Abstract

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