1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner, M. Christina White, Patrick Dolan, Thomas W Kensler, Shigefumi Yukihiro, Sandra E. Guggino

Research output: Contribution to journalArticle

Abstract

Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

Original languageEnglish (US)
Pages (from-to)2919-2924
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number24
DOIs
StatePublished - Dec 22 1994

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Calcitriol
Bioactivity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain. / Posner, Gary H.; White, M. Christina; Dolan, Patrick; Kensler, Thomas W; Yukihiro, Shigefumi; Guggino, Sandra E.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 24, 22.12.1994, p. 2919-2924.

Research output: Contribution to journalArticle

Posner, Gary H. ; White, M. Christina ; Dolan, Patrick ; Kensler, Thomas W ; Yukihiro, Shigefumi ; Guggino, Sandra E. / 1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 24. pp. 2919-2924.
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