1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner; M. Christina White; Patrick Dolan; Thomas W. Kensler; Shigefumi Yukihiro; Sandra E. Guggino

doi:10.1016/S0960-894X(01)80840-4

1α,25-dihydroxyvitamin D₃ hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Gary H. Posner, M. Christina White, Patrick Dolan, Thomas W. Kensler, Shigefumi Yukihiro, Sandra E. Guggino

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

Original language	English (US)
Pages (from-to)	2919-2924
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(01)80840-4
State	Published - Dec 22 1994

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80840-4

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title = "1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain",

abstract = "Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.",

author = "Posner, {Gary H.} and White, {M. Christina} and Patrick Dolan and Kensler, {Thomas W.} and Shigefumi Yukihiro and Guggino, {Sandra E.}",

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T1 - 1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

AU - Posner, Gary H.

AU - White, M. Christina

AU - Dolan, Patrick

AU - Kensler, Thomas W.

AU - Yukihiro, Shigefumi

AU - Guggino, Sandra E.

PY - 1994/12/22

Y1 - 1994/12/22

N2 - Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

AB - Calcitrol analogs 5, designed to combine two remote structural changes each of which separately produces a sharply different biological profile, have biological activities that are a blending of the effects of each structural change.

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VL - 4

SP - 2919

EP - 2924

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

1α,25-dihydroxyvitamin D₃ hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

Abstract

ASJC Scopus subject areas

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