σ receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP

Brian L. Largent, Andrew L. Gundlach, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

(+)[3H]SKF 10,047 and (+)[3H]3-PPP label a homogeneous population of sites in NCB-20 cell membranes that apparently represent benzomorphan specific binding sites previously reported for this cell line. Their drug specificity indicates that these sites are very similar to σ receptor binding sites labeled in brain tissues by these ligands and do not represent PCP receptors.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalEuropean Journal of Pharmacology
Volume124
Issue number1-2
DOIs
StatePublished - May 13 1986

Fingerprint

Hybrid Cells
Benzomorphans
Phencyclidine Receptors
Binding Sites
Cell Membrane
Ligands
Cell Line
Brain
Pharmaceutical Preparations
Population
preclamol

Keywords

  • (+)[H]3-PPP
  • (+)[H]SKF 10,047
  • Benzomorphan
  • NCB-20 cells
  • PCP receptors
  • σ Receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

σ receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP. / Largent, Brian L.; Gundlach, Andrew L.; Snyder, Solomon H.

In: European Journal of Pharmacology, Vol. 124, No. 1-2, 13.05.1986, p. 183-187.

Research output: Contribution to journalArticle

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