ζ-Crystallin is a major protein in the lens of Camelus dromedarius

Donita Garland, P. Vasantha Rao, Antonella Del Corso, Umberto Mura, J. Samuel Zigler

Research output: Contribution to journalArticlepeer-review

Abstract

Camel (Camelus dromedarius) lenses contain a protein with an apparent subunit Mr 38,000 that constitutes approximately 8-13% of the total protein. The protein has been purified and has a native Mr 140,000 as determined by gel filtration. This is consistent with its being a tetramer. The protein reacts with antibodies raised against both guinea pig ζ-crystallin and peptides corresponding to amino acids 1-10 and 295-308, but not to antibodies raised against amino acids 320-328 of ζ-crystallin. Based on these criteria it is concluded that this protein, which is a major constituent of camel lens, is ζ-crystallin. This may be the first example of a protein (enzyme) being independently utilized as a crystallin in the lens of species from two mammalian orders.

Original languageEnglish (US)
Pages (from-to)134-136
Number of pages3
JournalArchives of Biochemistry and Biophysics
Volume285
Issue number1
DOIs
StatePublished - Feb 15 1991

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'ζ-Crystallin is a major protein in the lens of Camelus dromedarius'. Together they form a unique fingerprint.

Cite this