γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid ρ1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ- aminobutyric acid responses in Xenopus oocytes

S. Shimada, G. Cutting, G. R. Uhl

Research output: Contribution to journalArticlepeer-review

Abstract

Xenopus oocyte expression of the recently cloned γ-aminobutyric acid (GABA)(ρ1) receptor subunit cDNA yields a pharmacologic profile characteristic of the GABA(c) responses described by Johnston [Benzodiazepine/GABA Receptors and Chloride Channels. Receptor Biochemistry and Methodology (R. W. Olsen and J. C. Venter, eds.), Vol. 5. Alan R. Liss, New York, 57-71 (1986)] and the responses to retinal mRNA recently reported in the Xenopus expression system [Proc. Natl. Acad. Sci. USA 88:4318-4322 (1991)]. A rationale for defining GABA (ρ1) as forming a GABA(c) receptor is discussed.

Original languageEnglish (US)
Pages (from-to)683-687
Number of pages5
JournalMolecular Pharmacology
Volume41
Issue number4
StatePublished - Dec 1 1992

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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