Abstract
Mice lacking αβ T-cells or γδ T-cells were infected with Plasmodium yoelii 17X NL (non-lethal) and followed for parasitaemia and cytokine production. While the parasitaemia in wild type mice resolved after reaching a peak value of 30 to 50%, it persisted in the -αβ T-cell mice until death. However, in the -γδ T-cell mice the peak parasitaemia was 12.5% of the levels seen in the wild type and -αβ T-cell mice and resolved faster than in the wild type mice. Higher levels of IL-10 and IFN-γ were consistently found in the wild type and -γδ T-cell mice but not in the -αβ T-cell mice.
Original language | English (US) |
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Pages (from-to) | 737-742 |
Number of pages | 6 |
Journal | International Journal for Parasitology |
Volume | 29 |
Issue number | 5 |
DOIs | |
State | Published - May 1999 |
Externally published | Yes |
Keywords
- Knock-out mice
- Malaria
- Plasmodium yoelii
- γδ T-cells
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases