γδ T-cells may interfere with a productive immune response in Plasmodium yoelii infections

Jeffrey Kopacz, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

Mice lacking αβ T-cells or γδ T-cells were infected with Plasmodium yoelii 17X NL (non-lethal) and followed for parasitaemia and cytokine production. While the parasitaemia in wild type mice resolved after reaching a peak value of 30 to 50%, it persisted in the -αβ T-cell mice until death. However, in the -γδ T-cell mice the peak parasitaemia was 12.5% of the levels seen in the wild type and -αβ T-cell mice and resolved faster than in the wild type mice. Higher levels of IL-10 and IFN-γ were consistently found in the wild type and -γδ T-cell mice but not in the -αβ T-cell mice.

Original languageEnglish (US)
Pages (from-to)737-742
Number of pages6
JournalInternational Journal for Parasitology
Volume29
Issue number5
DOIs
StatePublished - May 1 1999

Keywords

  • Knock-out mice
  • Malaria
  • Plasmodium yoelii
  • γδ T-cells

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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