β1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex

Richard Belvindrah, Diana Graus-Porta, Sandra Goebbels, Klaus Armin Nave, Ulrich Müller

Research output: Contribution to journalArticlepeer-review

Abstract

Radial glial cells in the cerebral cortex serve as progenitors for neurons and glia and guide the migration of cortical neurons. The integrin α3β1 is thought to mediate interactions of migrating neurons with radial glial cells and to function as a receptor for the reelin signaling molecule. Here, we challenge this view and demonstrate that β1 integrins in migrating neurons are not essential for the formation of cell layers in the cerebral cortex. Cortical cell layers also form normally in mice deficient in the integrin α3β1. However, we provide evidence that β1 integrins in radial glia control the morphological differentiation of both glia and neurons. We conclude that β1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas β1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling.

Original languageEnglish (US)
Pages (from-to)13854-13865
Number of pages12
JournalJournal of Neuroscience
Volume27
Issue number50
DOIs
StatePublished - Dec 12 2007
Externally publishedYes

Keywords

  • Cell migration
  • Cerebral cortex
  • Integrin
  • Nervous system
  • Radial glia
  • Reelin

ASJC Scopus subject areas

  • Neuroscience(all)

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