β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

S. E. Antonarakis, J. A. Phillips, R. L. Mallonee, H. H. Kazazian, E. R. Fearon, P. G. Waber, H. M. Kronenberg, A. Ullrich, D. A. Meyers

Research output: Contribution to journalArticlepeer-review

Abstract

Using a parathyroid hormone (PTH) cDNA probe we found a common Pst I polymorphic restriction site 3' to the PTH gene in all ethnic groups examined. Because the PTH, insulin, and β-globin loci have been localized to the short arm of chromosome 11 (11p) we used DNA polymorphisms adjacent to each of these three loci to determine whether they are genetically linked and to determine their order. We found that the PTH and β-globin loci are closely linked (estimated recombination fraction, 0.07; 95% confidence limits, 0.05-0.10; lod score, 4.63; odds favoring linkage, 42,000:1). Furthermore, our findings strongly indicate that the β-globin gene cluster lies between the PTH and insulin loci. Therefore, the gene order on 11p is centromere-PTH-β-globin-insulin.

Original languageEnglish (US)
Pages (from-to)6615-6619
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number21 I
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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