β-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

Wendy Kelder, Justin C. McArthur, Tish Nance-Sproson, Daniel McClernon, Diane E. Griffin

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus-associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-negative and HIV-positive individuals with and without neurological disease. Monocyte chemotactic protein (MCP)-1 and RANTES (but not MCP-3), macrophage inflammatory protein (MIP)-1α, MIP-1β, or interleukin-8 (IL-8) was higher in HAD. MCP-1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
JournalAnnals of neurology
Volume44
Issue number5
DOIs
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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