β-Catenin signaling in prostate cancer: An early perspective

D. R. Chesire, William B Isaacs

Research output: Contribution to journalArticle

Abstract

Further understanding of the molecular mechanisms responsible for prostate cancer (CaP) development and progression is paramount for overcoming the current diagnostic and therapeutic hurdles presented by this urologic disease. The β-catenin nuclear signaling molecule has been widely implicated as an oncogene in human cancer, including CaP. Pooling together knowledge gathered on the contributions of β-catenin and other factors to human neoplasia may assist in the development of better strategies for management and treatment of prostate tumors of all stages (early, advanced/androgen-dependent, advanced/androgen-independent). Although there is considerable lack of comprehension regarding the function of β-catenin transcriptional activity in prostate tumors in vivo, recent evidence indicates the probability that β-catenin contributes to multiple signaling pathways for which a causative role in CaP is already known. In this review, we will approach such pathway interactions, perhaps the most notable being androgen receptor (AR) signaling, in order to highlight those avenues through which β-catenin may exert its cancer-related function. To the same end, we will draw attention to normal β-catenin signaling in the prostate; however, as only very limited knowledge exists on this topic, much of the discussion will be correlative. Our final topic will concentrate on how, given realistic scenarios of androgen stimulation or absence in both normal and neoplastic prostate cells, nuclear β-catenin may ultimately potentiate wnt cell-cell signaling and AR activities. Heightening our comprehension of β-catenin signaling mechanisms and its phenotypic consequences in CaP - and in normal prostate - may contribute to that body of knowledge which will eventually prove useful for devising more effective therapies.

Original languageEnglish (US)
Pages (from-to)537-560
Number of pages24
JournalEndocrine-Related Cancer
Volume10
Issue number4
DOIs
StatePublished - Dec 2003

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Catenins
Prostatic Neoplasms
Prostate
Androgens
Androgen Receptors
Neoplasms
Urologic Diseases
Oncogenes
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

β-Catenin signaling in prostate cancer : An early perspective. / Chesire, D. R.; Isaacs, William B.

In: Endocrine-Related Cancer, Vol. 10, No. 4, 12.2003, p. 537-560.

Research output: Contribution to journalArticle

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