β-Catenin expression in thymocytes accelerates thymic involution

Youyuan Xu, Jyoti Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Age-related thymic involution in mammals is accompanied by decreased generation of naïve T cells without significant reduction in the number of peripheral T cells. This leads to inefficient immune responses and inadequate combating of infections and other challenges to the immune system in older mammals. The molecular mechanisms that underlie this phenomenon are not known. In this report we show that expression of β-catenin in thymocytes enhances thymic involution. The effect of β-catenin expression is seen in all the thymic subpopulations, suggesting that an age-related developmental process is accelerated. We also show that, as in normal mice, thymic involution does not lead to a drastic reduction in splenic T cells in β-catenin-transgenic mice. This study identifies β-catenin expression in thymocytes as a molecular target of age-related thymic involution.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalEuropean Journal of Immunology
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • β-Catenin
  • Aging
  • Thymic involution

ASJC Scopus subject areas

  • Immunology

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