β-catenin expression enchances generation of mature thymocytes

Thomas Mulroy, Youyuan Xu, Jyoti Misra Sen

Research output: Contribution to journalArticle

Abstract

T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that β-catenin, a central effector in the Wnt-TCF-1 signalling pathway, regulates late stages of T cell development. Specifically, transgenic expression of β-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-β-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.

Original languageEnglish (US)
Pages (from-to)1485-1494
Number of pages10
JournalInternational Immunology
Volume15
Issue number12
DOIs
StatePublished - Dec 2003
Externally publishedYes

Fingerprint

Catenins
T Cell Transcription Factor 1
Thymocytes
T-Lymphocytes
Transcription Factors
Genes

Keywords

  • Positive selection
  • Signal transduction
  • Thymocyte maturation
  • Thymus
  • Wnt signaling

ASJC Scopus subject areas

  • Immunology

Cite this

β-catenin expression enchances generation of mature thymocytes. / Mulroy, Thomas; Xu, Youyuan; Sen, Jyoti Misra.

In: International Immunology, Vol. 15, No. 12, 12.2003, p. 1485-1494.

Research output: Contribution to journalArticle

Mulroy, Thomas ; Xu, Youyuan ; Sen, Jyoti Misra. / β-catenin expression enchances generation of mature thymocytes. In: International Immunology. 2003 ; Vol. 15, No. 12. pp. 1485-1494.
@article{d78dd3fb98c14914bd0f66171708e568,
title = "β-catenin expression enchances generation of mature thymocytes",
abstract = "T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that β-catenin, a central effector in the Wnt-TCF-1 signalling pathway, regulates late stages of T cell development. Specifically, transgenic expression of β-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-β-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.",
keywords = "Positive selection, Signal transduction, Thymocyte maturation, Thymus, Wnt signaling",
author = "Thomas Mulroy and Youyuan Xu and Sen, {Jyoti Misra}",
year = "2003",
month = "12",
doi = "10.1093/intimm/dxg146",
language = "English (US)",
volume = "15",
pages = "1485--1494",
journal = "International Immunology",
issn = "0953-8178",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - β-catenin expression enchances generation of mature thymocytes

AU - Mulroy, Thomas

AU - Xu, Youyuan

AU - Sen, Jyoti Misra

PY - 2003/12

Y1 - 2003/12

N2 - T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that β-catenin, a central effector in the Wnt-TCF-1 signalling pathway, regulates late stages of T cell development. Specifically, transgenic expression of β-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-β-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.

AB - T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that β-catenin, a central effector in the Wnt-TCF-1 signalling pathway, regulates late stages of T cell development. Specifically, transgenic expression of β-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-β-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.

KW - Positive selection

KW - Signal transduction

KW - Thymocyte maturation

KW - Thymus

KW - Wnt signaling

UR - http://www.scopus.com/inward/record.url?scp=0347407819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347407819&partnerID=8YFLogxK

U2 - 10.1093/intimm/dxg146

DO - 10.1093/intimm/dxg146

M3 - Article

C2 - 14645157

AN - SCOPUS:0347407819

VL - 15

SP - 1485

EP - 1494

JO - International Immunology

JF - International Immunology

SN - 0953-8178

IS - 12

ER -