β-catenin expression enchances generation of mature thymocytes

Thomas Mulroy, Youyuan Xu, Jyoti Misra Sen

Research output: Contribution to journalArticle

Abstract

T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that β-catenin, a central effector in the Wnt-TCF-1 signalling pathway, regulates late stages of T cell development. Specifically, transgenic expression of β-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-β-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.

Original languageEnglish (US)
Pages (from-to)1485-1494
Number of pages10
JournalInternational Immunology
Volume15
Issue number12
DOIs
StatePublished - Dec 2003
Externally publishedYes

Keywords

  • Positive selection
  • Signal transduction
  • Thymocyte maturation
  • Thymus
  • Wnt signaling

ASJC Scopus subject areas

  • Immunology

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