β-catenin affects androgen receptor transcriptional activity and ligand specificity

C. I. Truica, S. Byers, E. P. Gelmann

Research output: Contribution to journalArticle

Abstract

β-Catenin is a multifunctional molecule with important roles in intercellular adhesion and signal transduction. We reported previously that β-catenin is mutated in human prostate cancer. In this study, we investigated the role of β-catenin mutations on androgen receptor (AR) signaling. β-Catenin significantly enhanced androgen-stimulated transcriptional activation by the AR. β-Catenin also increased AR transcriptional activation by androstenedione and estradiol and diminished the antagonism of bicalutamide. Coimmunoprecipitation of β-catenin with AR from LNCaP prostate cancer cells showed that the two molecules are present in the same complex. The amount of β-catenin in complex with AR was increased by androgen. These findings implicate β-catenin in the regulation of AR function and support a role for β-catenin mutations in the pathogenesis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)4709-4713
Number of pages5
JournalCancer Research
Volume60
Issue number17
StatePublished - Sep 1 2000
Externally publishedYes

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Catenins
Androgen Receptors
Ligands
Prostatic Neoplasms
Transcriptional Activation
Androgens
Mutation
Androstenedione
Estradiol
Signal Transduction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Truica, C. I., Byers, S., & Gelmann, E. P. (2000). β-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Research, 60(17), 4709-4713.

β-catenin affects androgen receptor transcriptional activity and ligand specificity. / Truica, C. I.; Byers, S.; Gelmann, E. P.

In: Cancer Research, Vol. 60, No. 17, 01.09.2000, p. 4709-4713.

Research output: Contribution to journalArticle

Truica, CI, Byers, S & Gelmann, EP 2000, 'β-catenin affects androgen receptor transcriptional activity and ligand specificity', Cancer Research, vol. 60, no. 17, pp. 4709-4713.
Truica, C. I. ; Byers, S. ; Gelmann, E. P. / β-catenin affects androgen receptor transcriptional activity and ligand specificity. In: Cancer Research. 2000 ; Vol. 60, No. 17. pp. 4709-4713.
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