β-Blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction

Hideaki Senzaki, Nazareno Paolocci, Yehezkiel A. Gluzband, Merry L. Lindsey, Joseph S. Janicki, Michael T. Crow, David A Kass

Research output: Contribution to journalArticle

Abstract

Angiotensin II (Ang II)-mediated sympathostimulation may worsen the progression of cardiac failure, although the nature and mechanisms of such interactions are largely unknown. We previously demonstrated that Ang II combined with evolving cardiodepression (48-hour tachycardia pacing, 48hP) induces marked chamber stiffening and increases metalloproteinases (MMPs). Here, we test the hypothesis that both abnormalities stem from sympathostimulatory effects of Ang II. Forty-eight dogs were instrumented to serially assess conscious ventricular mechanics, MMP abundance and activity, and myocardial histopathology. 48hP combined with 5 days of Ang II (15±5 ng · kg-1 min-1 IV) more than doubled chamber stiffness (end-diastolic pressure >25 mm Hg, P

Original languageEnglish (US)
Pages (from-to)807-815
Number of pages9
JournalCirculation Research
Volume86
Issue number7
StatePublished - Apr 14 2000

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Metalloproteases
Angiotensin II
Matrix Metalloproteinases
Tachycardia
Mechanics
Heart Failure
Dogs
Blood Pressure

Keywords

  • β-receptor blocker
  • Angiotensin II
  • Diastole
  • Heart failure
  • Metalloproteinase

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

β-Blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction. / Senzaki, Hideaki; Paolocci, Nazareno; Gluzband, Yehezkiel A.; Lindsey, Merry L.; Janicki, Joseph S.; Crow, Michael T.; Kass, David A.

In: Circulation Research, Vol. 86, No. 7, 14.04.2000, p. 807-815.

Research output: Contribution to journalArticle

Senzaki, Hideaki ; Paolocci, Nazareno ; Gluzband, Yehezkiel A. ; Lindsey, Merry L. ; Janicki, Joseph S. ; Crow, Michael T. ; Kass, David A. / β-Blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction. In: Circulation Research. 2000 ; Vol. 86, No. 7. pp. 807-815.
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AU - Janicki, Joseph S.

AU - Crow, Michael T.

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