β-adrenergic stimulation modulation of heart rate via synchronization of ryanodine receptor Ca2+ release

Edward G. Lakatta, Tatiana M. Vinogradova, Konstantin Y. Bogdanov

Research output: Contribution to journalArticlepeer-review

Abstract

A robust "fight or flight response", largely mediated via acute β-adrenergic receptor (β-AR) stimulation to the heart to increase its beating rate and contractile performance, is an essential component of the vertebrate survival instinct. While it has long been recognized that activation of β-AR increases the spontaneous beating rate of sinoatrial nodal cells (SANC), specific links between stimulation of β-ARs and the resultant increase in firing rate have not been evaluated. Our recent studies1,2 employed imaging of subcellular Ca2+ release coupled with recording of membrane potential or current in single, isolated cardiac SANC, to seek novel links between β-AR stimulation and ryanodine receptor Ca2+ release and heart rate. An overview of these recent results, which provides novel insights into mechanisms of cardiac reserve that underlie the "fight or flight instinct, is presented here.

Original languageEnglish (US)
Pages (from-to)451-461
Number of pages11
JournalJournal of Cardiac Surgery
Volume17
Issue number5
StatePublished - Sep 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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