β 1, 4-oligoglucosides inhibit the binding of aspergillus fumigatus conidia to human monocytes

Virginia L. Kan, John E. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley βglucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1, 3) and cellobiose (β1, 4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1, 4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of β1, 4-linked glucose residues led to greater inhibition of conidial binding by human monocytes.

Original languageEnglish (US)
Pages (from-to)1154-1156
Number of pages3
JournalJournal of Infectious Diseases
Volume163
Issue number5
DOIs
StatePublished - May 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'β 1, 4-oligoglucosides inhibit the binding of aspergillus fumigatus conidia to human monocytes'. Together they form a unique fingerprint.

Cite this