αB-Crystallin negative astrocytic inclusions

Brad P. Barnett, Joseph Bressler, Terina Chen, Grover M. Hutchins, Barbara J. Crain, Walter E. Kaufmann

Research output: Contribution to journalArticlepeer-review

Abstract

We report on an unusual pathological finding of astrocytes, observed in the brain of a 16-year-old African-American male with severe intellectual disability and spastic quadriplegia. The brain showed bilateral pericentral, perisylvian polymicrogyria and pachygyria, in conjunction with a large number of hypertrophic astrocytes with eosinophilic granular cytoplasmic inclusions. The astrocytic abnormality was more severe in the dysgenetic area but present throughout the cerebral cortex. Astrocytic inclusions stained with acid fuchsin, azocarmine and Holzer's stain, and were immunoreactive for GFAP, S-100, and ubiquitin, but not for αB-crystallin, filamin, vimentin, nestin, tau or α-synuclein. Based on the case and a review of the literature, the authors postulate that these astrocytic inclusions in the cerebral cortex reflect abnormalities in radial glial developmental processes, such as migration, differentiation, or glial-neuronal interaction function during neuronal migration.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalBrain and Development
Volume33
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Astrocytic change
  • Cerebral cortex
  • Eosinophilic inclusions
  • Neuronal migration disorder

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Fingerprint Dive into the research topics of 'αB-Crystallin negative astrocytic inclusions'. Together they form a unique fingerprint.

Cite this