α‐ADRENOCEPTORS CAN MEDIATE CHRONOTROPIC RESPONSES IN THE RAT HEART

N. A. FLAVAHAN, J. C. McGRATH

Research output: Contribution to journalArticlepeer-review

Abstract

In the pithed rat, amidephrine, a ‘selective’ α1‐adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that α1‐adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline. 1981 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)586-588
Number of pages3
JournalBritish Journal of Pharmacology
Volume73
Issue number3
DOIs
StatePublished - Jul 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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