α-Particle-emitter radiopharmaceutical therapy: Resistance is futile

Research output: Contribution to journalReview articlepeer-review

Abstract

Alpha-emitter radiopharmaceutical therapy (α-RPT) is a treatment modality that is impervious to conventional cellular resistance mechanisms because of the unique properties of the α-particle. Radiobiological studies of α-particle emitters have been few as they require detailed consideration of both biology and physics. Clinical studies of this radiation delivery modality have shown highly promising results in cancers that are resistant to other treatments. The work by Yard and colleagues published in this issue introduces an innovative approach to radiobiological investigations of α-RPT and highlights the specific physics considerations required to properly investigate this multidisciplinary treatment modality.

Original languageEnglish (US)
Pages (from-to)5479-5481
Number of pages3
JournalCancer Research
Volume79
Issue number21
DOIs
StatePublished - Nov 1 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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