α-methylacyl-CoA racemase: A variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy

Cristina Magi-Galluzzi, Jun Luo, William B. Isaacs, Jessica L. Hicks, Angelo M. De Marzo, Jonathan I. Epstein

Research output: Contribution to journalArticle

Abstract

Expression of the α-methylacyl-CoA racemase (AMACR) gene has recently been demonstrated by several groups to be markedly elevated in prostate cancer cells with little expression in benign prostate tissue and has been suggested as a molecular marker of prostate cancer on needle biopsy. There is scant data, however, as to the sensitivity and specificity of AMACR in the diagnosis of small foci of cancer on needle biopsy. A total of 209 needle biopsies of the prostate with small foci (

Original languageEnglish (US)
Pages (from-to)1128-1133
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2003

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Racemases and Epimerases
Needle Biopsy
Coenzyme A
Prostatic Neoplasms
Prostate
Sensitivity and Specificity
Genes
Neoplasms

Keywords

  • α-Methylacyl-CoA racemase
  • Prostate needle biopsy
  • Small prostate cancer

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

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abstract = "Expression of the α-methylacyl-CoA racemase (AMACR) gene has recently been demonstrated by several groups to be markedly elevated in prostate cancer cells with little expression in benign prostate tissue and has been suggested as a molecular marker of prostate cancer on needle biopsy. There is scant data, however, as to the sensitivity and specificity of AMACR in the diagnosis of small foci of cancer on needle biopsy. A total of 209 needle biopsies of the prostate with small foci (",
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AU - Luo, Jun

AU - Isaacs, William B.

AU - Hicks, Jessica L.

AU - De Marzo, Angelo M.

AU - Epstein, Jonathan I.

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AB - Expression of the α-methylacyl-CoA racemase (AMACR) gene has recently been demonstrated by several groups to be markedly elevated in prostate cancer cells with little expression in benign prostate tissue and has been suggested as a molecular marker of prostate cancer on needle biopsy. There is scant data, however, as to the sensitivity and specificity of AMACR in the diagnosis of small foci of cancer on needle biopsy. A total of 209 needle biopsies of the prostate with small foci (

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