TY - JOUR
T1 - β 1, 4-oligoglucosides inhibit the binding of aspergillus fumigatus conidia to human monocytes
AU - Kan, Virginia L.
AU - Bennett, John E.
PY - 1991/5
Y1 - 1991/5
N2 - The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley βglucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1, 3) and cellobiose (β1, 4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1, 4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of β1, 4-linked glucose residues led to greater inhibition of conidial binding by human monocytes.
AB - The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley βglucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1, 3) and cellobiose (β1, 4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1, 4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of β1, 4-linked glucose residues led to greater inhibition of conidial binding by human monocytes.
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U2 - 10.1093/infdis/163.5.1154
DO - 10.1093/infdis/163.5.1154
M3 - Article
C2 - 2019764
AN - SCOPUS:0025824302
SN - 0022-1899
VL - 163
SP - 1154
EP - 1156
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -