α4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development

Karen A. Pinco; Stephen Liu; Joy T. Yang

doi:10.1016/S0925-4773(00)00503-7

α4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development

Karen A. Pinco, Stephen Liu, Joy T. Yang

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

By RNA in situ hybridization and immunohistochemical analyses of early stage mouse embryos, we find that α4 integrin gene is expressed in migratory cranial neural crest cells originating from the presumptive forebrain, midbrain, and rhombomeres 1 and 2 of the presumptive hindbrain. α4 is also expressed in epicardial progenitor cells in the septum transversum that migrate to the heart. (C) 2001 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	99-103
Number of pages	5
Journal	Mechanisms of Development
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4773(00)00503-7
State	Published - 2001

Keywords

Cell adhesion
Epicardium
Heart
Migration
Mouse development
Neural crest
Otic vesicle
α4 integrins

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(00)00503-7

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title = "α4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development",

abstract = "By RNA in situ hybridization and immunohistochemical analyses of early stage mouse embryos, we find that α4 integrin gene is expressed in migratory cranial neural crest cells originating from the presumptive forebrain, midbrain, and rhombomeres 1 and 2 of the presumptive hindbrain. α4 is also expressed in epicardial progenitor cells in the septum transversum that migrate to the heart. (C) 2001 Elsevier Science Ireland Ltd.",

keywords = "Cell adhesion, Epicardium, Heart, Migration, Mouse development, Neural crest, Otic vesicle, α4 integrins",

author = "Pinco, {Karen A.} and Stephen Liu and Yang, {Joy T.}",

note = "Funding Information: We thank Drs Brian Condie and Trevor Williams for generously providing the cDNA for Krox-20 and AP-2 probes. The work was supported by grants from the American Cancer Society (RPG-98-229-01-DDC), the W.W. Smith Charitable Trust (#H9602).",

year = "2001",

doi = "10.1016/S0925-4773(00)00503-7",

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T1 - α4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development

AU - Pinco, Karen A.

AU - Liu, Stephen

AU - Yang, Joy T.

N1 - Funding Information: We thank Drs Brian Condie and Trevor Williams for generously providing the cDNA for Krox-20 and AP-2 probes. The work was supported by grants from the American Cancer Society (RPG-98-229-01-DDC), the W.W. Smith Charitable Trust (#H9602).

PY - 2001

Y1 - 2001

N2 - By RNA in situ hybridization and immunohistochemical analyses of early stage mouse embryos, we find that α4 integrin gene is expressed in migratory cranial neural crest cells originating from the presumptive forebrain, midbrain, and rhombomeres 1 and 2 of the presumptive hindbrain. α4 is also expressed in epicardial progenitor cells in the septum transversum that migrate to the heart. (C) 2001 Elsevier Science Ireland Ltd.

AB - By RNA in situ hybridization and immunohistochemical analyses of early stage mouse embryos, we find that α4 integrin gene is expressed in migratory cranial neural crest cells originating from the presumptive forebrain, midbrain, and rhombomeres 1 and 2 of the presumptive hindbrain. α4 is also expressed in epicardial progenitor cells in the septum transversum that migrate to the heart. (C) 2001 Elsevier Science Ireland Ltd.

KW - Cell adhesion

KW - Epicardium

KW - Heart

KW - Migration

KW - Mouse development

KW - Neural crest

KW - Otic vesicle

KW - α4 integrins

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α4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development

Abstract

Keywords

ASJC Scopus subject areas

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