Research Output 1987 2018

2018
Cyclooxygenase 2
Dextrans
Small Interfering RNA
Down-Regulation
Acids

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts

Goggins, E., Kakkad, S., Mironchik, Y., Jacob, D., Wildes, F., Krishnamachary, B. & Bhujwalla, Z. M. Feb 1 2018 In : Neoplasia (United States). 20, 2, p. 131-139 9 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Heterografts
Collagen
Hypoxia
Neoplasms
2017

A PSMA-targeted theranostic agent for photodynamic therapy

Chen, Y., Chatterjee, S., Lisok, A., Minn, I., Pullambhatla, M., Wharram, B., Wang, Y., Jin, J., Bhujwalla, Z. M., Nimmagadda, S., Mease, R. C. & Pomper, M. G. Feb 1 2017 In : Journal of Photochemistry and Photobiology B: Biology. 167, p. 111-116 6 p.

Research output: Research - peer-reviewArticle

Photochemotherapy
human glutamate carboxypeptidase II
Theranostic Nanomedicine
antigens
therapy

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

Krishnamachary, B., Stasinopoulos, I., Kakkad, S., Penet, M. F., Jacob, D., Wildes, F., Mironchik, Y., Pathak, A. P., Solaiyappan, M. & Bhujwalla, Z. M. 2017 In : Oncotarget. 8, 11, p. 17981-17994 14 p.

Research output: Research - peer-reviewArticle

Cyclooxygenase 2
Extracellular Matrix
Breast Neoplasms
Cancer-Associated Fibroblasts
Neoplasms

Delayed progression of lung metastases following delivery of a prodrug-activating enzyme

Dore-Savard, L., Chen, Z., Winnard, P. T., Krishnamachary, B., Raman, V., Black, M. E. & Bhujwalla, Z. M. May 1 2017 In : Anticancer Research. 37, 5, p. 2195-2200 6 p.

Research output: Research - peer-reviewArticle

Prodrugs
Neoplasm Metastasis
Lung
Enzymes
Neoplasms

Editorial: Exploring Cancer Metabolic Reprogramming through Molecular Imaging

Podo, F., Bhujwalla, Z. M. & Iorio, E. Apr 26 2017 In : Frontiers in Oncology. 7, APR, 79

Research output: Research - peer-reviewEditorial

Molecular Imaging
Energy Metabolism
Neoplasms

Metabolomic characterization of experimental ovarian cancer ascitic fluid

Bharti, S. K., Wildes, F., Hung, C. F., Wu, T. C., Bhujwalla, Z. M. & Penet, M. F. Oct 1 2017 In : Metabolomics. 13, 10, 113

Research output: Research - peer-reviewArticle

Cells
Fluids
Metabolomics
Ascitic Fluid
Ascites

Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer

Cheng, M., Rizwan, A., Jiang, L., Bhujwalla, Z. M. & Glunde, K. Aug 1 2017 In : Neoplasia (United States). 19, 8, p. 617-627 11 p.

Research output: Research - peer-reviewArticle

Choline
Doxorubicin
Breast Neoplasms
Therapeutics
Phosphorylcholine
Extracellular Matrix
Prostatic Neoplasms
Neoplasms
Collagen
Albumins
2016

A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts

Azad, B. B., Chatterjee, S., Lesniak, W. G., Lisok, A., Pullambhatla, M., Bhujwalla, Z. M., Pomper, M. G. & Nimmagadda, S. Mar 15 2016 In : Oncotarget. 7, 11, p. 12344-12358 15 p.

Research output: Research - peer-reviewArticle

CXCR4 Receptors
Heterografts
Antibodies
Neoplasms
Therapeutics

Choline metabolism alteration: A focus on ovarian cancer

Bagnoli, M., Granata, A., Nicoletti, R., Krishnamachary, B., Bhujwalla, Z. M., Canese, R., Podo, F., Canevari, S., Iorio, E. & Mezzanzanica, D. Jun 22 2016 In : Frontiers in Oncology. 6, JUN, 153

Research output: Research - peer-reviewShort survey

Choline
Ovarian Neoplasms
Neoplasms
Ovarian epithelial cancer
Phenotype

Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers

Kakkad, S., Zhang, J., Akhbardeh, A., Jacob, D., Krishnamachary, B., Solaiyappan, M., Jacobs, M. A., Raman, V., Leibfritz, D., Glunde, K. & Bhujwalla, Z. M. Oct 1 2016 In : Neoplasia (United States). 18, 10, p. 585-593 9 p.

Research output: Research - peer-reviewArticle

Anisotropy
Collagen
Breast Neoplasms
Water
Neoplasms
Choline Kinase
Dextrans
Small Interfering RNA
Dextran
RNA

Detection of pancreatic cancer-induced cachexia using a fluorescent myoblast reporter system and analysis of metabolite abundance

Winnard, P. T., Bharti, S. K., Penet, M. F., Marik, R., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Mar 15 2016 In : Cancer Research. 76, 6, p. 1441-1450 10 p.

Research output: Research - peer-reviewArticle

Cachexia
Myoblasts
Systems Analysis
Pancreatic Neoplasms
Weight Loss

Developing imidazoles as CEST MRI pH sensors

Yang, X., Song, X., Ray Banerjee, S., Li, Y., Byun, Y., Liu, G., Bhujwalla, Z. M., Pomper, M. G. & McMahon, M. T. Jul 1 2016 In : Contrast Media and Molecular Imaging. 11, 4, p. 304-312 9 p.

Research output: Research - peer-reviewArticle

Imidazoles
Magnetic Resonance Imaging
Heterocyclic Compounds
Intravenous Administration
Hydrogen
Cytosine Deaminase
Drug Compounding
Prodrugs
Enzymes
Therapeutics

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, M. F., Krishnamachary, B., Wildes, F., Mironchik, Y., Mezzanzanica, D., Podo, F., De Reggi, M., Gharib, B. & Bhujwalla, Z. M. Nov 16 2016 In : Frontiers in Oncology. 6, NOV, 244

Research output: Research - peer-reviewArticle

Choline
Neoplasms
pantethine
Therapeutics
Ovarian Neoplasms

Lymphatic endothelial cells actively regulate prostate cancer cell invasion

Shah, T., Wildes, F., Kakkad, S., Artemov, D. & Bhujwalla, Z. M. Jul 1 2016 In : NMR in Biomedicine. 29, 7, p. 904-911 8 p.

Research output: Research - peer-reviewArticle

Endothelial cells
Cells
Prostatic Neoplasms
Endothelial Cells
Degradation

Magnetic Resonance Imaging and Spectroscopy in Cancer Theranostic Imaging

Penet, M. F., Jin, J., Chen, Z. & Bhujwalla, Z. M. Jun 29 2016 (Accepted/In press) In : Topics in Magnetic Resonance Imaging.

Research output: Research - peer-reviewArticle

Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Neoplasms
Therapeutics
Theranostic Nanomedicine

Microglia activation in a pediatric rabbit model of tuberculous meningitis

Tucker, E. W., Pokkali, S., Zhang, Z., DeMarco, V. P., Klunk, M., Smith, E. S., Ordonez, A. A., Penet, M. F., Bhujwalla, Z., Jain, S. K. & Kannan, S. Dec 1 2016 In : DMM Disease Models and Mechanisms. 9, 12, p. 1497-1502 6 p.

Research output: Research - peer-reviewArticle

Meningeal Tuberculosis
Microglia
Pediatrics
Rabbits
Chemical activation

Phototheranostics of CD44-positive cell populations in triple negative breast cancer

Jin, J., Krishnamachary, B., Mironchik, Y., Kobayashi, H. & Bhujwalla, Z. M. Jun 15 2016 In : Scientific Reports. 6, 27871

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Population
Breast Neoplasms
Neoplastic Stem Cells
Neoplasms
Flucytosine
Prodrugs
Prostatic Neoplasms
Tumor Necrosis Factor-alpha
Apoptosis

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Cao, M. D., Cheng, M., Rizwan, A., Jiang, L., Krishnamachary, B., Bhujwalla, Z. M., Bathen, T. F. & Glunde, K. Aug 1 2016 In : NMR in Biomedicine. 29, 8, p. 1098-1107 10 p.

Research output: Research - peer-reviewArticle

Choline
Small Interfering RNA
Cell Movement
Phospholipids
Cell Proliferation

Targeting phospholipid metabolism in cancer

Cheng, M., Bhujwalla, Z. M. & Glunde, K. 2016 In : Frontiers in Oncology. 6, DEC, 266

Research output: Research - peer-reviewReview article

Phospholipids
Neoplasms
Therapeutics
Choline
Enzymes

The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts

Dore-Savard, L., Lee, E., Kakkad, S., Popel, A. S. & Bhujwalla, Z. M. Dec 20 2016 In : Scientific Reports. 6, 39460

Research output: Research - peer-reviewArticle

Heterografts
Vascular Endothelial Growth Factor A
Breast Neoplasms
Neoplasms
Extracellular Fluid

The tumor microenvironment modulates choline and lipid metabolism

Mori, N., Wildes, F., Takagi, T., Glunde, K. & Bhujwalla, Z. M. 2016 In : Frontiers in Oncology. 6, DEC, 262

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Choline
Lipid Metabolism
Neoplasms
Heterografts
2015

Cancer cachexia, recent advances, and future directions

Penet, M. F. & Bhujwalla, Z. M. Mar 9 2015 In : Cancer Journal (United States). 21, 2, p. 117-122 6 p.

Research output: Research - peer-reviewArticle

Cachexia
Neoplasms
Direction compound
Molecular Imaging
Nutritional Support
Choline Kinase
Phosphorylcholine
Phosphatidylcholines
Cell Survival
Breast Neoplasms
Choline
Neoplasms
Choline Kinase
Magnetic Resonance Spectroscopy
Therapeutics

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

Danhier, P., Krishnamachary, B., Bharti, S., Kakkad, S., Mironchik, Y. & Bhujwalla, Z. M. Dec 1 2015 In : Neoplasia (New York, N.Y.). 17, 12, p. 871-881 11 p.

Research output: Research - peer-reviewArticle

Neoplasms
Proteins
Hypoxia
enhanced green fluorescent protein
Luciferases

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S. S. Mar 1 2015 In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Research - peer-reviewArticle

Breast Neoplasms
Prostaglandins E
Therapeutics
Traction
Neoplasms

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Granata, A., Nicoletti, R., Perego, P., Iorio, E., Krishnamachary, B., Benigni, F., Ricci, A., Podo, F., Bhujwalla, Z. M., Canevari, S., Bagnoli, M. & Mezzanzanica, D. 2015 In : Oncotarget. 6, 13, p. 11216-11230 15 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Metabolome
Glutathione
Antioxidants
Carcinoma

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

Shah, T., Krishnamachary, B., Wildes, F., Mironchik, Y., Kakkad, S. M., Jacob, D., Artemov, D. & Bhujwalla, Z. M. 2015 In : Oncotarget. 6, 29, p. 28104-28119 16 p.

Research output: Research - peer-reviewArticle

Protein Isoforms
Neoplasm Metastasis
Hypoxia
Lipid Droplets
Cell Line

Magnetic resonance spectroscopy of siRNA-based cancer therapy

Penet, M. F., Chen, Z., Mori, N., Krishnamachary, B. & Bhujwalla, Z. M. 2015 Methods in Molecular Biology. Humana Press Inc., Vol. 1372, p. 37-47 11 p. (Methods in Molecular Biology; vol. 1372)

Research output: ResearchChapter

Small Interfering RNA
Magnetic Resonance Spectroscopy
Neoplasms
Therapeutics
Down-Regulation

MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model

Jiang, L., Chughtai, K., Purvine, S. O., Bhujwalla, Z. M., Raman, V., Paša-Tolić, L., Heeren, R. M. A. & Glunde, K. Jun 16 2015 In : Analytical Chemistry. 87, 12, p. 5947-5956 10 p.

Research output: Research - peer-reviewArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Breast Neoplasms
Lipids
Neoplasms
Proteins

Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism

Penet, M. F., Shah, T., Bharti, S., Krishnamachary, B., Artemov, D., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Jan 15 2015 In : Clinical Cancer Research. 21, 2, p. 386-395 10 p.

Research output: Research - peer-reviewArticle

Choline
Adenocarcinoma
choline transporter
Biomarkers
Choline Kinase

Metastatic breast cancer cells in lymph nodes increase nodal collagen density

Rizwan, A., Bulte, C., Kalaichelvan, A., Cheng, M., Krishnamachary, B., Bhujwalla, Z. M., Jiang, L. & Glunde, K. May 7 2015 In : Scientific Reports. 5, 10002

Research output: Research - peer-reviewArticle

Collagen
Lymph Nodes
Breast Neoplasms
Neoplasms
Heterografts

Synthesis and Evaluation of GdIII-Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen

Banerjee, S. R., Ngen, E. J., Rotz, M. W., Kakkad, S., Lisok, A., Pracitto, R., Pullambhatla, M., Chen, Z., Shah, T., Artemov, D., Meade, T. J., Bhujwalla, Z. M. & Pomper, M. G. Sep 1 2015 In : Angewandte Chemie - International Edition. 54, 37, p. 10778-10782 5 p.

Research output: Research - peer-reviewArticle

Molecular imaging
Magnetic resonance
Contrast Media
human glutamate carboxypeptidase II
Antigens

Targeting glutamine metabolism in breast cancer with aminooxyacetate

Korangath, P., Teo, W. W., Sadik, H., Han, L., Mori, N., Huijts, C. M., Wildes, F., Bharti, S., Zhang, Z., Santa-Maria, C. A., Tsai, H., Dang, C. V., Stearns, V., Bhujwalla, Z. M. & Sukumar, S. Jul 15 2015 In : Clinical Cancer Research. 21, 14, p. 3263-3273 11 p.

Research output: Research - peer-reviewArticle

Aminooxyacetic Acid
Glutamine
Breast Neoplasms
Cell Death
Endoplasmic Reticulum Stress
2014

A biomimetic collagen derived peptide exhibits anti- Angiogenic activity in triple negative breast cancer

Rosca, E. V., Penet, M. F., Mori, N., Koskimaki, J. E., Lee, E., Pandey, N. B., Bhujwalla, Z. M. & Popel, A. S. Nov 10 2014 In : PLoS One. 9, 11, e111901

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Biomimetics
Collagen
Peptides
biomimetics

Direct facile screening of recombinant DNA vector constructs

Winnard, P. T., Challa, R., Bhujwalla, Z. M. & Raman, V. Apr 1 2014 In : Analytical Biochemistry. 450, 1, p. 1-3 3 p.

Research output: Research - peer-reviewArticle

Recombinant DNA
Screening
Proteins
Fermentation
Agar
Precision Medicine
Molecular Imaging
Tumor Microenvironment
Neoplasms
Theranostic Nanomedicine

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer

Gadiya, M., Mori, N., Cao, M. D., Mironchik, Y., Kakkad, S., Gribbestad, I. S., Glunde, K., Krishnamachary, B. & Bhujwalla, Z. M. 2014 In : Cancer Biology and Therapy. 15, 5, p. 593-601 9 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Choline
Breast Neoplasms
phospholipase D1
Phospholipids

Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by 31P MRS

Wijnen, J. P., Jiang, L., Greenwood, T. R., Cheng, M., Döpkens, M., Cao, M. D., Bhujwalla, Z. M., Krishnamachary, B., Klomp, D. W. J. & Glunde, K. 2014 In : NMR in Biomedicine. 27, 6, p. 692-699 8 p.

Research output: Research - peer-reviewArticle

Metabolites
Tumors
Phospholipids
glycerophosphocholine phosphodiesterase
Breast Neoplasms

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics

Chen, L., Choyke, P. L., Wang, N., Clarke, R., Bhujwalla, Z. M., Hillman, E. M. C., Wang, G. & Wang, Y. Nov 7 2014 In : PLoS One. 9, 11, e112143

Research output: Research - peer-reviewArticle

blood vessels
image analysis
Deconvolution
Imaging techniques
Blood Vessels
2013

Characterization of choline kinase in human endothelial cells

Mori, N., Gadiya, M., Wildes, F., Krishnamachary, B., Glunde, K. & Bhujwalla, Z. M. Nov 2013 In : NMR in Biomedicine. 26, 11, p. 1501-1507 7 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Endothelial Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
Down-Regulation

COX-2 in cancer: Gordian knot or achilles heel?

Stasinopoulos, I., Shah, T., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M. 2013 In : Frontiers in Pharmacology. 4 MAR, Article 34

Research output: Research - peer-reviewArticle

Cyclooxygenase 2
Neoplasms
Neoplasm Metastasis
Lymphatic Vessels
Tumor Microenvironment

Fiber-optic multiphoton endomicroscopy

Liang, W., Hall, G., Zhang, Y., Akins, M. L., Xi, J., Li, M. J., Luby-Phelps, K., Mahendroo, M., Bhujwalla, Z., Glunde, K. & Li, X. 2013 Optics InfoBase Conference Papers. Optical Society of America

Research output: ResearchConference contribution

Fiber optics
Photons
Tissue
fiber optics
photons
Collagen
Neoplasms
collagen
neoplasms
Tumors
extracellular matrix
metastasis
breast neoplasms
phenotype
neoplasms