Zaver M Bhujwalla

Professor

1987 …2018
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Research Output 1987 2018

2018
Cyclooxygenase 2
Dextrans
Small Interfering RNA
Down-Regulation
Acids

Combined PET/MRI: Global Warming—Summary Report of the 6th International Workshop on PET/MRI, March 27–29, 2017, Tübingen, Germany

Bailey, D. L. , Pichler, B. J. , Gückel, B. , Antoch, G. , Barthel, H. , Bhujwalla, Z. M. , Biskup, S. , Biswal, S. , Bitzer, M. , Boellaard, R. , Braren, R. F. , Brendle, C. , Brindle, K. , Chiti, A. , la Fougère, C. , Gillies, R. , Goh, V. , Goyen, M. , Hacker, M. , Heukamp, L. & 16 others Knudsen, G. M., Krackhardt, A. M., Law, I., Morris, J. C., Nikolaou, K., Nuyts, J., Ordonez, A. A., Pantel, K., Quick, H. H., Riklund, K., Sabri, O., Sattler, B., Troost, E. G. C., Zaiss, M., Zender, L. & Beyer, T. Feb 1 2018 In : Molecular Imaging and Biology. 20, 1, p. 4-20 17 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Global Warming
Molecular Imaging
Pets
Neurology

Hypoxia-induced reporter genes with different half-lives

Krishnamachary, B., Danhier, P., Kakkad, S., Bharti, S. K. & Bhujwalla, Z. M. Jan 1 2018 Methods in Molecular Biology. Humana Press Inc., p. 113-125 13 p. (Methods in Molecular Biology; vol. 1790)

Research output: Chapter in Book/Report/Conference proceedingChapter

Reporter Genes
Half-Life
Preclinical Drug Evaluations
Molecular Imaging
Optical Imaging

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts

Goggins, E., Kakkad, S., Mironchik, Y., Jacob, D., Wildes, F., Krishnamachary, B. & Bhujwalla, Z. M. Feb 1 2018 In : Neoplasia (United States). 20, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Heterografts
Collagen
Extracellular Matrix
Cell Hypoxia

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft

Bharti, S. K., Mironchik, Y., Wildes, F., Penet, M. F., Goggins, E., Krishnamachary, B. & Bhujwalla, Z. M. Jan 1 2018 In : Oncotarget. 9, 20, p. 15326-15339 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Heterografts
Magnetic Resonance Spectroscopy
Neoplasms
Hypoxia
Disease control
Molecular imaging
Precision Medicine
Molecular Imaging
Oncology
2017

A PSMA-targeted theranostic agent for photodynamic therapy

Chen, Y., Chatterjee, S., Lisok, A., Minn, I., Pullambhatla, M., Wharram, B., Wang, Y., Jin, J., Bhujwalla, Z. M., Nimmagadda, S., Mease, R. C. & Pomper, M. G. Feb 1 2017 In : Journal of Photochemistry and Photobiology B: Biology. 167, p. 111-116 6 p.

Research output: Contribution to journalArticle

Photochemotherapy
antigens
therapy
membranes
tumors
Cyclooxygenase 2
Extracellular Matrix
Breast Neoplasms
Collagen
Down-Regulation

Delayed progression of lung metastases following delivery of a prodrug-activating enzyme

Dore-Savard, L., Chen, Z., Winnard, P. T., Krishnamachary, B., Raman, V., Black, M. E. & Bhujwalla, Z. M. May 1 2017 In : Anticancer Research. 37, 5, p. 2195-2200 6 p.

Research output: Contribution to journalArticle

Prodrugs
Cytosine Deaminase
Neoplasm Metastasis
Lung
Enzymes

Editorial: Exploring Cancer Metabolic Reprogramming through Molecular Imaging

Podo, F., Bhujwalla, Z. M. & Iorio, E. Apr 26 2017 In : Frontiers in Oncology. 7, APR, 79

Research output: Contribution to journalEditorial

Molecular Imaging
Energy Metabolism
Neoplasms

Metabolomic characterization of experimental ovarian cancer ascitic fluid

Bharti, S. K., Wildes, F., Hung, C. F., Wu, T. C., Bhujwalla, Z. M. & Penet, M. F. Oct 1 2017 In : Metabolomics. 13, 10, 113

Research output: Contribution to journalArticle

Metabolomics
Ascitic Fluid
Ascites
Ovarian Neoplasms
Cells

Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer

Cheng, M., Rizwan, A., Jiang, L., Bhujwalla, Z. M. & Glunde, K. Aug 1 2017 In : Neoplasia (United States). 19, 8, p. 617-627 11 p.

Research output: Contribution to journalArticle

Choline
Doxorubicin
Breast Neoplasms
Choline Kinase
Phosphorylcholine
Extracellular Matrix
Prostatic Neoplasms
Neoplasms
Collagen
Albumins
2016

A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts

Azad, B. B., Chatterjee, S., Lesniak, W. G., Lisok, A., Pullambhatla, M., Bhujwalla, Z. M., Pomper, M. G. & Nimmagadda, S. Mar 15 2016 In : Oncotarget. 7, 11, p. 12344-12358 15 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Heterografts
Antibodies
Neoplasms
Triple Negative Breast Neoplasms

Choline metabolism alteration: A focus on ovarian cancer

Bagnoli, M., Granata, A., Nicoletti, R., Krishnamachary, B., Bhujwalla, Z. M., Canese, R., Podo, F., Canevari, S., Iorio, E. & Mezzanzanica, D. Jun 22 2016 In : Frontiers in Oncology. 6, JUN, 153

Research output: Contribution to journalShort survey

Choline
Ovarian Neoplasms
Choline Kinase
Phenotype
Phospholipase D

Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers

Kakkad, S., Zhang, J., Akhbardeh, A., Jacob, D., Krishnamachary, B., Solaiyappan, M., Jacobs, M. A., Raman, V., Leibfritz, D., Glunde, K. & Bhujwalla, Z. M. Oct 1 2016 In : Neoplasia (United States). 18, 10, p. 585-593 9 p.

Research output: Contribution to journalArticle

Anisotropy
Collagen
Breast Neoplasms
Water
Diffusion Tensor Imaging
Choline Kinase
Dextran
Dextrans
RNA
Small Interfering RNA

Detection of pancreatic cancer-induced cachexia using a fluorescent myoblast reporter system and analysis of metabolite abundance

Winnard, P. T., Bharti, S. K., Penet, M. F., Marik, R., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Mar 15 2016 In : Cancer Research. 76, 6, p. 1441-1450 10 p.

Research output: Contribution to journalArticle

Cachexia
Myoblasts
Systems Analysis
Pancreatic Neoplasms
Weight Loss

Developing imidazoles as CEST MRI pH sensors

Yang, X., Song, X., Ray Banerjee, S., Li, Y., Byun, Y., Liu, G., Bhujwalla, Z. M., Pomper, M. G. & McMahon, M. T. Jul 1 2016 In : Contrast Media and Molecular Imaging. 11, 4, p. 304-312 9 p.

Research output: Contribution to journalArticle

Imidazoles
Magnetic Resonance Imaging
Heterocyclic Compounds
Intravenous Administration
Hydrogen
Cytosine Deaminase
Microencapsulation
Drug Compounding
Alginate
Prodrugs

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, M. F., Krishnamachary, B., Wildes, F., Mironchik, Y., Mezzanzanica, D., Podo, F., De Reggi, M., Gharib, B. & Bhujwalla, Z. M. Nov 16 2016 In : Frontiers in Oncology. 6, NOV, 244

Research output: Contribution to journalArticle

Choline
Neoplasms
Ovarian Neoplasms
Ascites
pantethine

Lymphatic endothelial cells actively regulate prostate cancer cell invasion

Shah, T., Wildes, F., Kakkad, S., Artemov, D. & Bhujwalla, Z. M. Jul 1 2016 In : NMR in Biomedicine. 29, 7, p. 904-911 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Prostatic Neoplasms
Endothelial Cells
Cells
Degradation
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Neoplasms
Precision Medicine
Therapeutics

Microglia activation in a pediatric rabbit model of tuberculous meningitis

Tucker, E. W., Pokkali, S., Zhang, Z., DeMarco, V. P., Klunk, M., Smith, E. S., Ordonez, A. A., Penet, M. F., Bhujwalla, Z., Jain, S. K. & Kannan, S. Dec 1 2016 In : DMM Disease Models and Mechanisms. 9, 12, p. 1497-1502 6 p.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Pediatrics
Microglia
Macrophages
Chemical activation

Phototheranostics of CD44-positive cell populations in triple negative breast cancer

Jin, J., Krishnamachary, B., Mironchik, Y., Kobayashi, H. & Bhujwalla, Z. M. Jun 15 2016 In : Scientific Reports. 6, 27871

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Population
Breast Neoplasms
Aldehyde Dehydrogenase
Cytosine Deaminase
Flucytosine
Prodrugs
Cell death
Antigens

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Cao, M. D., Cheng, M., Rizwan, A., Jiang, L., Krishnamachary, B., Bhujwalla, Z. M., Bathen, T. F. & Glunde, K. Aug 1 2016 In : NMR in Biomedicine. 29, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

Cell proliferation
Choline
Metabolism
Small Interfering RNA
Cell Movement

Targeting phospholipid metabolism in cancer

Cheng, M., Bhujwalla, Z. M. & Glunde, K. 2016 In : Frontiers in Oncology. 6, DEC, 266

Research output: Contribution to journalReview article

Phospholipids
Neoplasms
Choline
Ethanolamine
Enzymes

The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts

Dore-Savard, L., Lee, E., Kakkad, S., Popel, A. S. & Bhujwalla, Z. M. Dec 20 2016 In : Scientific Reports. 6, 39460

Research output: Contribution to journalArticle

Heterografts
Vascular Endothelial Growth Factor A
Extracellular Fluid
Breast Neoplasms
Neoplasms

The tumor microenvironment modulates choline and lipid metabolism

Mori, N., Wildes, F., Takagi, T., Glunde, K. & Bhujwalla, Z. M. 2016 In : Frontiers in Oncology. 6, DEC, 262

Research output: Contribution to journalArticle

Tumor Microenvironment
Choline
Lipid Metabolism
Neoplasms
Heterografts
2015

Cancer cachexia, recent advances, and future directions

Penet, M. F. & Bhujwalla, Z. M. Mar 9 2015 In : Cancer Journal (United States). 21, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Cachexia
Neoplasms
Molecular Imaging
Nutritional Support
Skeletal Muscle
Choline Kinase
Phosphorylcholine
Phosphatidylcholines
Cell Survival
Cells
Choline
Neoplasms
Choline Kinase
Magnetic Resonance Spectroscopy
Phospholipase D
Luciferases
Neoplasms
Proteins
Response Elements
Prostatic Neoplasms

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S. S. Mar 1 2015 In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Prostaglandins E
Traction
Mechanical Phenomena
Biological Phenomena

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Granata, A., Nicoletti, R., Perego, P., Iorio, E., Krishnamachary, B., Benigni, F., Ricci, A., Podo, F., Bhujwalla, Z. M., Canevari, S., Bagnoli, M. & Mezzanzanica, D. 2015 In : Oncotarget. 6, 13, p. 11216-11230 15 p.

Research output: Contribution to journalArticle

Choline Kinase
Metabolome
Glutathione
Antioxidants
Carcinoma

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

Shah, T., Krishnamachary, B., Wildes, F., Mironchik, Y., Kakkad, S. M., Jacob, D., Artemov, D. & Bhujwalla, Z. M. 2015 In : Oncotarget. 6, 29, p. 28104-28119 16 p.

Research output: Contribution to journalArticle

Protein Isoforms
Neoplasm Metastasis
Hypoxia
Lipid Droplets
Cell Hypoxia

Magnetic resonance spectroscopy of siRNA-based cancer therapy

Penet, M. F., Chen, Z., Mori, N., Krishnamachary, B. & Bhujwalla, Z. M. 2015 Methods in Molecular Biology. Humana Press Inc., Vol. 1372, p. 37-47 11 p. (Methods in Molecular Biology; vol. 1372)

Research output: Chapter in Book/Report/Conference proceedingChapter

Small Interfering RNA
Magnetic Resonance Spectroscopy
Neoplasms
Therapeutics
Choline Kinase

MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model

Jiang, L., Chughtai, K., Purvine, S. O., Bhujwalla, Z. M., Raman, V., Paša-Tolić, L., Heeren, R. M. A. & Glunde, K. Jun 16 2015 In : Analytical Chemistry. 87, 12, p. 5947-5956 10 p.

Research output: Contribution to journalArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Tumors
Breast Neoplasms
Lipids
Imaging techniques

Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism

Penet, M. F., Shah, T., Bharti, S., Krishnamachary, B., Artemov, D., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Jan 15 2015 In : Clinical Cancer Research. 21, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Choline
Adenocarcinoma
Choline Kinase
Biomarkers
Tumor Cell Line

Metastatic breast cancer cells in lymph nodes increase nodal collagen density

Rizwan, A., Bulte, C., Kalaichelvan, A., Cheng, M., Krishnamachary, B., Bhujwalla, Z. M., Jiang, L. & Glunde, K. May 7 2015 In : Scientific Reports. 5, 10002

Research output: Contribution to journalArticle

Collagen
Lymph Nodes
Breast Neoplasms
Heterografts
Extracellular Matrix

Synthesis and Evaluation of GdIII-Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen

Banerjee, S. R., Ngen, E. J., Rotz, M. W., Kakkad, S., Lisok, A., Pracitto, R., Pullambhatla, M., Chen, Z., Shah, T., Artemov, D., Meade, T. J., Bhujwalla, Z. M. & Pomper, M. G. Sep 1 2015 In : Angewandte Chemie - International Edition. 54, 37, p. 10778-10782 5 p.

Research output: Contribution to journalArticle

Molecular imaging
Magnetic resonance
Antigens
Contrast Media
Membranes

Targeting glutamine metabolism in breast cancer with aminooxyacetate

Korangath, P., Teo, W. W., Sadik, H., Han, L., Mori, N., Huijts, C. M., Wildes, F., Bharti, S., Zhang, Z., Santa-Maria, C. A., Tsai, H., Dang, C. V., Stearns, V., Bhujwalla, Z. M. & Sukumar, S. Jul 15 2015 In : Clinical Cancer Research. 21, 14, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Aminooxyacetic Acid
Glutamine
Breast Neoplasms
Endoplasmic Reticulum Stress
Cell Death
2014

A biomimetic collagen derived peptide exhibits anti- Angiogenic activity in triple negative breast cancer

Rosca, E. V., Penet, M. F., Mori, N., Koskimaki, J. E., Lee, E., Pandey, N. B., Bhujwalla, Z. M. & Popel, A. S. Nov 10 2014 In : PLoS One. 9, 11, e111901

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
biomimetics
Biomimetics
breast neoplasms
collagen

Direct facile screening of recombinant DNA vector constructs

Winnard, P. T., Challa, R., Bhujwalla, Z. M. & Raman, V. Apr 1 2014 In : Analytical Biochemistry. 450, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Recombinant DNA
Screening
Fermentation
Agar
Assays
Precision Medicine
Molecular Imaging
Tumor Microenvironment
Neoplasms
Stromal Cells

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer

Gadiya, M., Mori, N., Cao, M. D., Mironchik, Y., Kakkad, S., Gribbestad, I. S., Glunde, K., Krishnamachary, B. & Bhujwalla, Z. M. 2014 In : Cancer Biology and Therapy. 15, 5, p. 593-601 9 p.

Research output: Contribution to journalArticle

Choline Kinase
Choline
Breast Neoplasms
Phosphorylcholine
Phospholipids

Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by 31P MRS

Wijnen, J. P., Jiang, L., Greenwood, T. R., Cheng, M., Döpkens, M., Cao, M. D., Bhujwalla, Z. M., Krishnamachary, B., Klomp, D. W. J. & Glunde, K. 2014 In : NMR in Biomedicine. 27, 6, p. 692-699 8 p.

Research output: Contribution to journalArticle

Metabolites
Tumors
Phospholipids
Breast Neoplasms
Choline

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity and repopulation dynamics

Chen, L., Choyke, P. L., Wang, N., Clarke, R., Bhujwalla, Z. M., Hillman, E. M. C., Wang, G. & Wang, Y. Nov 7 2014 In : PLoS One. 9, 11, e112143

Research output: Contribution to journalArticle

Deconvolution
blood vessels
Blood Vessels
image analysis
Imaging techniques
2013

Characterization of choline kinase in human endothelial cells

Mori, N., Gadiya, M., Wildes, F., Krishnamachary, B., Glunde, K. & Bhujwalla, Z. M. Nov 2013 In : NMR in Biomedicine. 26, 11, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Choline Kinase
Endothelial cells
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Down-Regulation