Zack Z. Wang

Associate Professor

1990 …2019
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Research Output 1990 2019

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2010 International Forum on Stem Cells (November 11-13; Tianjin, China)

Sipp, D., Wang, Z. Z. & Yuan, W., Sep 2011, In : Stem Cell Reviews and Reports. 7, 3, p. 479-481 3 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Biomedical Research
China
Stem Cells

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

Kuang, S. Q., Bai, H., Fang, Z. H., Lopez, G., Yang, H., Tong, W., Wang, Z. Z. & Garcia-Manero, G., Mar 25 2010, In : Blood. 115, 12, p. 2412-2419 8 p.

Research output: Contribution to journalArticle

Eph Family Receptors
Ephrins
DNA Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epigenomics

Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Jan 2012, In : Stem Cell Research. 8, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Cell Survival
Apoptosis
Human Embryonic Stem Cells
Embryoid Bodies
Gene Expression

BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway

Bai, H., Gao, Y., Arzigian, M., Wojchowski, D. M., Wu, W. S. & Wang, Z. Z., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

Stem cells
Blood Vessels
Cell Differentiation
Muscle
Cells

Cell-Type-Specific Predictive Network Yields Novel Insights into Mouse Embryonic Stem Cell Self-Renewal and Cell Fate

Dowell, K. G., Simons, A. K., Wang, Z. Z., Yun, K. & Hibbs, M. A., Feb 28 2013, In : PLoS One. 8, 2, e56810.

Research output: Contribution to journalArticle

embryonic stem cells
Stem cells
stem cells
Stem Cells
Biological Phenomena

Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity

Wang, Z. Z., Sicinski, P., Weinberg, R. A., Zhang, Y. & Ravid, K., Jul 1 1996, In : Genomics. 35, 1, p. 156-163 8 p.

Research output: Contribution to journalArticle

Cyclin D3
Introns
Exons
Cyclins
Transcription Initiation Site

Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily

Bennett, B. D., Wang, Z. Z., Kuang, W. J., Wang, A., Groopman, J. E., Goeddel, D. V. & Scadden, D. T., May 13 1994, In : Journal of Biological Chemistry. 269, 19, p. 14211-14218 8 p.

Research output: Contribution to journalArticle

Cloning
Protein-Tyrosine Kinases
Organism Cloning
Cells
EphB4 Receptor

Cloning of FRK, a novel human intracellular SRC-like tyrosine kinaseencoding gene

Lee, J., Wang, Z. Z., Luoh, S. M., Wood, W. I. & Scadden, D. T., Jan 28 1994, In : Gene. 138, 1-2, p. 247-251 5 p.

Research output: Contribution to journalArticle

Tyrosine
Organism Cloning
Clone Cells
Protein-Tyrosine Kinases
Amino Acid Sequence

Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells

Xie, Y., Bai, H., Liu, Y., Hoyle, D. L., Cheng, T. & Wang, Z. Z., Dec 1 2015, In : Journal of Cellular Biochemistry. 116, 12, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Human Development
Erythropoietin
Stem cells
Erythroid Cells

Corrigendum to "Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal" [Stem Cell Res. 8 (2012) 26-37]

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Nov 2013, In : Stem Cell Research. 11, 3, p. 1272 1 p.

Research output: Contribution to journalArticle

Cell Survival
Human Embryonic Stem Cells
corrigendum
Cell Self Renewal

Cyclin D3 is essential for megakaryocytopoiesis

Wang, Z. Z., Zhang, Y., Kamen, D., Lees, E. & Ravid, K., 1995, In : Blood. 86, 10, p. 3783-3788 6 p.

Research output: Contribution to journalArticle

Cyclin D3
Thrombopoiesis
Megakaryocytes
Cyclin B1
Cyclins

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 1 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Primitive Streak
Activins
Pluripotent Stem Cells
Bone Morphogenetic Proteins
Stem cells

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z., May 1 2016, In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Hemangioblasts
Pluripotent Stem Cells
Endothelial cells
Hematopoietic Stem Cells
Stem cells

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Shao, L., Sun, Y., Zhang, Z., Feng, W., Gao, Y., Cai, Z., Wang, Z. Z., Look, A. T. & Wu, W. S., Jun 10 2010, In : Blood. 115, 23, p. 4707-4714 8 p.

Research output: Contribution to journalArticle

Puma
Hematopoietic Stem Cells
Stem cells
Dosimetry
Radiation

Development of hematopoietic stem and progenitor cells from human pluripotent stem cells

Chen, T., Wang, F., Wu, M. & Wang, Z. Z., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. V

Research output: Contribution to journalArticle

Signal transduction
Stem cells
Endothelial cells
Blood
Medicine

Directing human embryonic stem cells to generate vascular progenitor cells

Bai, H. & Wang, Z. Z., Jan 2008, In : Gene Therapy. 15, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Stem Cells
Smooth Muscle Myocytes
Endothelial Cells
Vascular Diseases

Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds

Zhang, Z., Gao, Y., Gordon, A., Wang, Z. Z., Qian, Z. & Wu, W. S., 2011, In : PLoS One. 6, 10, e26592.

Research output: Contribution to journalArticle

retroviral vectors
Induced Pluripotent Stem Cells
Chemical compounds
chemical compounds
Stem cells

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents

Liu, Y., Wang, Y., Wang, Y., Wang, Y., Gao, Y., Gao, Y., Forbes, J. A., Qayyum, R., Becker, L., Cheng, L., Cheng, L., Wang, Z. Z. & Wang, Z. Z., 2015, In : Stem cells translational medicine. 4, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Megakaryocytes
United States Food and Drug Administration
Pharmacology
oprelvekin

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Wang, Z. Z., Au, P., Chen, T., Shao, Y., Daheron, L. M., Bai, H., Arzigian, M., Fukumura, D., Jain, R. K. & Scadden, D. T., Mar 2007, In : Nature Biotechnology. 25, 3, p. 317-318 2 p.

Research output: Contribution to journalArticle

Embryoid Bodies
SCID Mice
Endothelial cells
Blood vessels
Cardiovascular System

Endothelial cells regulate cardiomyocyte development from embryonic stem cells

Chen, K., Bai, H., Arzigian, M., Gao, Y. X., Bao, J., Wu, W. S., Shen, W. F., Wu, L. & Wang, Z. Z., Sep 1 2010, In : Journal of Cellular Biochemistry. 111, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Endothelial cells
Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Endothelial Cells

EphB4 Forward-Signaling Regulates Cardiac Progenitor Development in Mouse ES Cells

Chen, K., Bai, H., Liu, Y., Hoyle, D. L., Shen, W. F., Wu, L. Q. & Wang, Z. Z., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 467-475 9 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Stem Cells
EphA1 Receptor

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels

Wang, Z. Z., Cohen, K., Shao, Y., Mole, P., Dombkowski, D. & Scadden, D. T., Jan 1 2004, In : Blood. 103, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

Hemangioblasts
Eph Family Receptors
Blood vessels
Embryonic Stem Cells
Stem cells

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Chen, T., You, Y., Jiang, H. & Wang, Z. Z., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Biological Phenomena
Epithelial-Mesenchymal Transition
Stem cells
Cell Differentiation
Carcinogenesis

Establishment of sprouting embryoid body model mimicking early embryonic vasculogenesis in human embryo

Jiang, H., Feng, Y. J., Xie, Y., Han, J. L., Wang, Z. Z. & Chen, T., Oct 14 2008, In : Zhonghua yi xue za zhi. 88, 37, p. 2647-2651 5 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Fibroblast Growth Factors
Vascular Endothelial Growth Factor A
Embryonic Structures
Angiostatins

Expression of alternatively spliced isoforms of platelet endothelial cell adhesion molecule-1 of embryonic stem cells during vasculogenesis and angiogenesis

Li, Z. J., Xu, B., Li, Y. H., Lu, S. H., Zheng, Y. Z., Yang, R. C., Wang, Z. Z., Qian, G. Q. & Han, Z. C., May 25 2005, In : Zhonghua yi xue za zhi. 85, 19, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

CD31 Antigens
Embryonic Stem Cells
Protein Isoforms
Exons
CD15 Antigens

Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells

Chen, K., Wu, L. & Wang, Z. Z., May 1 2008, In : Journal of Cellular Biochemistry. 104, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Tissue
Muscle

F-box protein 10, an NF-B-κdependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway

Ge, R., Wang, Z. Z., Zeng, Q., Xu, X. & Olumi, A. F., Jul 2011, In : Cell Death and Differentiation. 18, 7, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

F-Box Proteins
Apoptosis Regulatory Proteins
Apoptosis
Transcription Factor AP-1
Neoplasms

Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame

Shao, L., Feng, W., Sun, Y., Bai, H., Liu, J., Currie, C., Kim, J., Gama, R., Wang, Z. Z., Qian, Z., Liaw, L. & Wu, W. S., Mar 2009, In : Cell Research. 19, 3, p. 296-306 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Open Reading Frames
Transgenes
Transcription Factors
Virus Integration

Hemato-endothelial differentiation from lentiviral-transduced human embryonic stem cells retains durable reporter gene expression under the control of ubiquitin promoter

Jiang, H., Lin, X., Feng, Y., Xie, Y., Han, J., Zhang, Y., Wang, Z. Z. & Chen, T., Jan 2010, In : Cytotechnology. 62, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Ubiquitin
Stem cells
Reporter Genes
Gene expression
Gene Expression

Hematopoietic SCT in patients with a history of invasive fungal infection

Zhang, P., Song, A., Wang, Z. Z., Feng, S., Qiu, L. & Han, M., 2009, In : Bone Marrow Transplantation. 43, 7, p. 533-537 5 p.

Research output: Contribution to journalArticle

Antifungal Agents
Transplantation
Invasive Fungal Infections
Infection
Adrenal Cortex Hormones

HIV-1 suppresses erythropoietin production in vitro

Wang, Z. Z., Goldberg, M. A. & Scadden, D. T., 1993, In : Experimental Hematology. 21, 5, p. 683-688 6 p.

Research output: Contribution to journalArticle

Erythropoietin
HIV-1
Acquired Immunodeficiency Syndrome
In Vitro Techniques
Proteins

Human immunodeficiency virus infection of human bone marrow stromal fibroblasts

Scadden, D. T., Zeira, M., Woon, A., Wang, Z. Z., Schieve, L., Ikeuchi, K., Lim, B. & Groopman, J. E., Jul 15 1990, In : Blood. 76, 2, p. 317-322 6 p.

Research output: Contribution to journalArticle

Virus Diseases
Fibroblasts
Viruses
Bone
Bone Marrow

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity

Gallo, K. A., Mark, M. R., Scadden, D. T., Wang, Z. Z., Gu, Q. & Godowski, P. J., May 27 1994, In : Journal of Biological Chemistry. 269, 21, p. 15092-15100 9 p.

Research output: Contribution to journalArticle

src Homology Domains
Protein-Serine-Threonine Kinases
Proline
Phosphotransferases
Protein Kinases
megakaryocytes
Induced Pluripotent Stem Cells
Megakaryocytes
Stem cells
transcriptomics

In vitro vasculogenesis and angiogenesis of mouse embryonic stem cells

Li, Z. J., Yang, C., Tang, F. W., Zhang, Z. H., Xu, B., Zhao, Q. J., Yang, R. C., Wang, Z. Z. & Han, Z. C., Feb 2005, In : Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.. 27, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

Embryoid Bodies
CD31 Antigens
Smooth Muscle
Blood Vessels
Endothelial Cells

In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia

Scadden, D. T., Levine, J. D., Bresnahan, J., Gere, J., McGrath, J., Wang, Z. Z., Resta, D. J., Young, D. & Hammer, S. M., 1995, In : AIDS Research and Human Retroviruses. 11, 6, p. 731-740 10 p.

Research output: Contribution to journalArticle

Interleukin-3
HIV-1
Leukocyte Count
Eosinophils
Hemoglobins

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation

Li, Z. J., Wang, Z. Z., Zheng, Y. Z., Xu, B., Yang, R. C., Scadden, D. T. & Han, Z. C., Jun 1 2005, In : Journal of Cellular Biochemistry. 95, 3, p. 559-570 12 p.

Research output: Contribution to journalArticle

CD31 Antigens
Embryonic Stem Cells
Stem cells
Cell Differentiation
Kinetics

Mechanisms that mediate stem cell self-renewal and differentiation

Zhang, H. & Wang, Z. Z., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 709-718 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Stem Cells
Adult Stem Cells
Neoplastic Stem Cells

Mpl ligand enhances the transcription of the cyclin D3 gene: A potential role for Sp1 transcription factor

Wang, Z. Z., Zhang, Y., Lu, J., Sun, S. & Ravid, K., Jun 15 1999, In : Blood. 93, 12, p. 4208-4221 14 p.

Research output: Contribution to journalArticle

Cyclin D3
Sp1 Transcription Factor
Thrombopoietin
Transcription
Genes

Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis

Tang, Y., Bai, H., Urs, S., Wang, Z. Z. & Liaw, L., 2013, In : Transgenic Research. 22, 2, p. 403-410 8 p.

Research output: Contribution to journalArticle

hematopoiesis
cadherins
Hematopoiesis
Hematopoietic Stem Cells
Mesonephros

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks

Dowell, K. G., Simons, A. K., Bai, H., Kell, B., Wang, Z. Z., Yun, K. & Hibbs, M. A., 2014, In : Stem Cells. 32, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Systems Biology
Embryonic Stem Cells
Genes
Leukemia Inhibitory Factor
Developmental Biology

Priming of Toll-like receptor 4 pathway in mesenchymal stem cells increases expression of B cell activating factor

Yan, H., Wu, M., Yuan, Y., Wang, Z. Z., Jiang, H. & Chen, T., May 30 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 212-217 6 p.

Research output: Contribution to journalArticle

B-Cell Activating Factor
Toll-Like Receptor 4
Stem cells
Mesenchymal Stromal Cells
Toll-Like Receptors

Quantitation of plasma human immunodeficiency virus type 1 rna by competitive polymerase chain reaction

Scadden, D. T., Wang, Z. Z. & Groopman, J. E., 1992, In : Journal of Infectious Diseases. 165, 6, p. 1119-1123 5 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
HIV-1
Polymerase Chain Reaction
Complementary RNA
RNA

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells

Wang, Z. Z., Miura, N., Bonelli, A., Mole, P., Carlesso, N., Olson, D. P. & Scadden, D. T., Apr 15 2002, In : Blood. 99, 8, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Bone
Cells
Ligands
Genistein

Role of BET Bromodomain in Hematopoietic Differentiation from hESCs

Feng, Z. C., Wen, Y. Q., Wang, M. G., Tu, Q., Wang, H. T., Wang, Z. Z. & Zhou, J. X., Aug 1 2018, In : Zhongguo shi yan xue ye xue za zhi. 26, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Fluorescent Antibody Technique
Real-Time Polymerase Chain Reaction
Flow Cytometry
Hemangioblasts

Signaling by the Mpl receptor involves IKK and NF-κB

Zhang, Y., Sun, S., Wang, Z. Z., Thompson, A., Kaluzhny, Y., Zimmet, J. & Ravid, K., 2002, In : Journal of Cellular Biochemistry. 85, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

Thrombopoietin
Megakaryocytes
Cells
Apoptosis
DNA

Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration

Sun, Y., Shao, L., Bai, H., Wang, Z. Z. & Wu, W. S., Mar 4 2010, In : Blood. 115, 9, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

Gastropoda
Hematopoietic Stem Cells
Stem cells
Regeneration
Transcription Factors

Stem cell science on the rise in China

Yuan, W., Sipp, D., Wang, Z. Z., Deng, H., Pei, D., Zhou, Q. & Cheng, T., Jan 6 2012, In : Cell Stem Cell. 10, 1, p. 12-15 4 p.

Research output: Contribution to journalArticle

Clinical Governance
Stem Cell Research
China
Stem Cells
Growth

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro

Chen, T., Bai, H., Shao, Y., Arzigian, M., Janzen, V., Attar, E., Xie, Y., Scadden, D. T. & Wang, Z. Z., Feb 2007, In : Stem Cells. 25, 2, p. 392-401 10 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Endothelium
Organizations
Blood Vessels
Embryoid Bodies
Pluripotent Stem Cells
Cell Aging
Transforming Growth Factors
Endothelial Cells
Blood Vessels