Zack Z. Wang

Associate Professor

1990 …2019

Research output per year

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Research Output

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2019

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 1 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

2018

Role of BET Bromodomain in Hematopoietic Differentiation from hESCs

Feng, Z. C., Wen, Y. Q., Wang, M. G., Tu, Q., Wang, H. T., Wang, Z. Z. & Zhou, J. X., Aug 1 2018, In : Zhongguo shi yan xue ye xue za zhi. 26, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

2017

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Chen, T., You, Y., Jiang, H. & Wang, Z. Z., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

2016

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z., May 1 2016, In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

2015

Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells

Xie, Y., Bai, H., Liu, Y., Hoyle, D. L., Cheng, T. & Wang, Z. Z., Dec 1 2015, In : Journal of Cellular Biochemistry. 116, 12, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

Development of hematopoietic stem and progenitor cells from human pluripotent stem cells

Chen, T., Wang, F., Wu, M. & Wang, Z. Z., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. V

Research output: Contribution to journalArticle

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents

Liu, Y., Wang, Y., Wang, Y., Wang, Y., Gao, Y., Gao, Y., Forbes, J. A., Qayyum, R., Becker, L., Cheng, L., Cheng, L., Wang, Z. Z. & Wang, Z. Z., 2015, In : Stem cells translational medicine. 4, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

EphB4 Forward-Signaling Regulates Cardiac Progenitor Development in Mouse ES Cells

Chen, K., Bai, H., Liu, Y., Hoyle, D. L., Shen, W. F., Wu, L. Q. & Wang, Z. Z., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 467-475 9 p.

Research output: Contribution to journalArticle

2014

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks

Dowell, K. G., Simons, A. K., Bai, H., Kell, B., Wang, Z. Z., Yun, K. & Hibbs, M. A., 2014, In : Stem Cells. 32, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Priming of Toll-like receptor 4 pathway in mesenchymal stem cells increases expression of B cell activating factor

Yan, H., Wu, M., Yuan, Y., Wang, Z. Z., Jiang, H. & Chen, T., May 30 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 212-217 6 p.

Research output: Contribution to journalArticle

2013

Cell-Type-Specific Predictive Network Yields Novel Insights into Mouse Embryonic Stem Cell Self-Renewal and Cell Fate

Dowell, K. G., Simons, A. K., Wang, Z. Z., Yun, K. & Hibbs, M. A., Feb 28 2013, In : PLoS One. 8, 2, e56810.

Research output: Contribution to journalArticle

Corrigendum to "Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal" [Stem Cell Res. 8 (2012) 26-37]

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Nov 2013, In : Stem Cell Research. 11, 3, p. 1272 1 p.

Research output: Contribution to journalArticle

Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis

Tang, Y., Bai, H., Urs, S., Wang, Z. Z. & Liaw, L., 2013, In : Transgenic Research. 22, 2, p. 403-410 8 p.

Research output: Contribution to journalArticle

The balance of positive and negative effects of TGF-β signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells

Bai, H., Xie, Y. L., Gao, Y. X., Cheng, T. & Wang, Z. Z., Oct 15 2013, In : Stem Cells and Development. 22, 20, p. 2765-2776 12 p.

Research output: Contribution to journalArticle

2012

Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Jan 2012, In : Stem Cell Research. 8, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Stem cell science on the rise in China

Yuan, W., Sipp, D., Wang, Z. Z., Deng, H., Pei, D., Zhou, Q. & Cheng, T., Jan 6 2012, In : Cell Stem Cell. 10, 1, p. 12-15 4 p.

Research output: Contribution to journalArticle

2011

2010 International Forum on Stem Cells (November 11-13; Tianjin, China)

Sipp, D., Wang, Z. Z. & Yuan, W., Sep 2011, In : Stem Cell Reviews and Reports. 7, 3, p. 479-481 3 p.

Research output: Contribution to journalArticle

Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds

Zhang, Z., Gao, Y., Gordon, A., Wang, Z. Z., Qian, Z. & Wu, W. S., 2011, In : PLoS One. 6, 10, e26592.

Research output: Contribution to journalArticle

F-box protein 10, an NF-B-κdependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway

Ge, R., Wang, Z. Z., Zeng, Q., Xu, X. & Olumi, A. F., Jul 2011, In : Cell Death and Differentiation. 18, 7, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

2010

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

Kuang, S. Q., Bai, H., Fang, Z. H., Lopez, G., Yang, H., Tong, W., Wang, Z. Z. & Garcia-Manero, G., Mar 25 2010, In : Blood. 115, 12, p. 2412-2419 8 p.

Research output: Contribution to journalArticle

BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway

Bai, H., Gao, Y., Arzigian, M., Wojchowski, D. M., Wu, W. S. & Wang, Z. Z., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Shao, L., Sun, Y., Zhang, Z., Feng, W., Gao, Y., Cai, Z., Wang, Z. Z., Look, A. T. & Wu, W. S., Jun 10 2010, In : Blood. 115, 23, p. 4707-4714 8 p.

Research output: Contribution to journalArticle

Endothelial cells regulate cardiomyocyte development from embryonic stem cells

Chen, K., Bai, H., Arzigian, M., Gao, Y. X., Bao, J., Wu, W. S., Shen, W. F., Wu, L. & Wang, Z. Z., Sep 1 2010, In : Journal of Cellular Biochemistry. 111, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Hemato-endothelial differentiation from lentiviral-transduced human embryonic stem cells retains durable reporter gene expression under the control of ubiquitin promoter

Jiang, H., Lin, X., Feng, Y., Xie, Y., Han, J., Zhang, Y., Wang, Z. Z. & Chen, T., Jan 2010, In : Cytotechnology. 62, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration

Sun, Y., Shao, L., Bai, H., Wang, Z. Z. & Wu, W. S., Mar 4 2010, In : Blood. 115, 9, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

2009

Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame

Shao, L., Feng, W., Sun, Y., Bai, H., Liu, J., Currie, C., Kim, J., Gama, R., Wang, Z. Z., Qian, Z., Liaw, L. & Wu, W. S., Mar 2009, In : Cell Research. 19, 3, p. 296-306 11 p.

Research output: Contribution to journalArticle

Hematopoietic SCT in patients with a history of invasive fungal infection

Zhang, P., Song, A., Wang, Z. Z., Feng, S., Qiu, L. & Han, M., 2009, In : Bone Marrow Transplantation. 43, 7, p. 533-537 5 p.

Research output: Contribution to journalArticle

2008

Directing human embryonic stem cells to generate vascular progenitor cells

Bai, H. & Wang, Z. Z., Jan 2008, In : Gene Therapy. 15, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

Establishment of sprouting embryoid body model mimicking early embryonic vasculogenesis in human embryo

Jiang, H., Feng, Y. J., Xie, Y., Han, J. L., Wang, Z. Z. & Chen, T., Oct 14 2008, In : Zhonghua yi xue za zhi. 88, 37, p. 2647-2651 5 p.

Research output: Contribution to journalArticle

Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells

Chen, K., Wu, L. & Wang, Z. Z., May 1 2008, In : Journal of Cellular Biochemistry. 104, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Mechanisms that mediate stem cell self-renewal and differentiation

Zhang, H. & Wang, Z. Z., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 709-718 10 p.

Research output: Contribution to journalArticle

2007

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Wang, Z. Z., Au, P., Chen, T., Shao, Y., Daheron, L. M., Bai, H., Arzigian, M., Fukumura, D., Jain, R. K. & Scadden, D. T., Mar 2007, In : Nature Biotechnology. 25, 3, p. 317-318 2 p.

Research output: Contribution to journalArticle

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro

Chen, T., Bai, H., Shao, Y., Arzigian, M., Janzen, V., Attar, E., Xie, Y., Scadden, D. T. & Wang, Z. Z., Feb 2007, In : Stem Cells. 25, 2, p. 392-401 10 p.

Research output: Contribution to journalArticle

2005

Expression of alternatively spliced isoforms of platelet endothelial cell adhesion molecule-1 of embryonic stem cells during vasculogenesis and angiogenesis

Li, Z. J., Xu, B., Li, Y. H., Lu, S. H., Zheng, Y. Z., Yang, R. C., Wang, Z. Z., Qian, G. Q. & Han, Z. C., May 25 2005, In : Zhonghua yi xue za zhi. 85, 19, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

In vitro vasculogenesis and angiogenesis of mouse embryonic stem cells

Li, Z. J., Yang, C., Tang, F. W., Zhang, Z. H., Xu, B., Zhao, Q. J., Yang, R. C., Wang, Z. Z. & Han, Z. C., Feb 2005, In : Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.. 27, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation

Li, Z. J., Wang, Z. Z., Zheng, Y. Z., Xu, B., Yang, R. C., Scadden, D. T. & Han, Z. C., Jun 1 2005, In : Journal of Cellular Biochemistry. 95, 3, p. 559-570 12 p.

Research output: Contribution to journalArticle

2004

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels

Wang, Z. Z., Cohen, K., Shao, Y., Mole, P., Dombkowski, D. & Scadden, D. T., Jan 1 2004, In : Blood. 103, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

2002

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells

Wang, Z. Z., Miura, N., Bonelli, A., Mole, P., Carlesso, N., Olson, D. P. & Scadden, D. T., Apr 15 2002, In : Blood. 99, 8, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

Signaling by the Mpl receptor involves IKK and NF-κB

Zhang, Y., Sun, S., Wang, Z. Z., Thompson, A., Kaluzhny, Y., Zimmet, J. & Ravid, K., 2002, In : Journal of Cellular Biochemistry. 85, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

Thymocyte emigration is mediated by active movement away from stroma-derived factors

Poznansky, M. C., Olszak, I. T., Evans, R. H., Wang, Z. Z., Foxall, R. B., Olson, D. P., Weibrecht, K., Luster, A. D. & Scadden, D. T., 2002, In : Journal of Clinical Investigation. 109, 8, p. 1101-1110 10 p.

Research output: Contribution to journalArticle

2000

The impact of hepatitis B virus infected patients or donors on the outcome of hematopoietic stem cell transplantation

Feng, S., Han, M., Zhang, L., Li, C., Qiu, L., Li, H., Wang, Z. Z., Jiang, R., Yan, W. & Han, Z., 2000, In : Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 21, 8, p. 414-416 3 p.

Research output: Contribution to journalArticle

The receptor tyrosine kinase, EphB4 (HTK), promotes megakaryocytic and erythroid differentiation

Wang, Z. Z., Miura, N., Bonelli, A., Mole, P. & Scadden, D. T., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

1999

Mpl ligand enhances the transcription of the cyclin D3 gene: A potential role for Sp1 transcription factor

Wang, Z. Z., Zhang, Y., Lu, J., Sun, S. & Ravid, K., Jun 15 1999, In : Blood. 93, 12, p. 4208-4221 14 p.

Research output: Contribution to journalArticle

1998

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes

Zhang, Y., Wang, Z. Z., Liu, D. X., Pagano, M. & Ravid, K., Jan 16 1998, In : Journal of Biological Chemistry. 273, 3, p. 1387-1392 6 p.

Research output: Contribution to journalArticle

1996

Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity

Wang, Z. Z., Sicinski, P., Weinberg, R. A., Zhang, Y. & Ravid, K., Jul 1 1996, In : Genomics. 35, 1, p. 156-163 8 p.

Research output: Contribution to journalArticle

The cell cycle in polyploid megakaryoeytes is associated with reduced activity of cyclin B1-dependent Cdc2 kinase

Zhang, Y., Wang, Z. Z. & Ravid, K., Feb 23 1996, In : Journal of Biological Chemistry. 271, 8, p. 4266-4272 7 p.

Research output: Contribution to journalArticle

1995

Cyclin D3 is essential for megakaryocytopoiesis

Wang, Z. Z., Zhang, Y., Kamen, D., Lees, E. & Ravid, K., 1995, In : Blood. 86, 10, p. 3783-3788 6 p.

Research output: Contribution to journalArticle

In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia

Scadden, D. T., Levine, J. D., Bresnahan, J., Gere, J., McGrath, J., Wang, Z. Z., Resta, D. J., Young, D. & Hammer, S. M., 1995, In : AIDS Research and Human Retroviruses. 11, 6, p. 731-740 10 p.

Research output: Contribution to journalArticle