Zack Z. Wang

Associate Professor

1990 …2019
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Research Output 1990 2019

2019

Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling

Shen, J., Lyu, C., Zhu, Y., Feng, Z., Zhang, S., Hoyle, D. L., Ji, G., Brodsky, R. A., Cheng, T. & Wang, Z. Z., Jan 1 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Primitive Streak
Activins
Pluripotent Stem Cells
Bone Morphogenetic Proteins
Stem cells
2018

Role of BET Bromodomain in Hematopoietic Differentiation from hESCs

Feng, Z. C., Wen, Y. Q., Wang, M. G., Tu, Q., Wang, H. T., Wang, Z. Z. & Zhou, J. X., Aug 1 2018, In : Zhongguo shi yan xue ye xue za zhi. 26, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Fluorescent Antibody Technique
Real-Time Polymerase Chain Reaction
Flow Cytometry
Hemangioblasts
2017

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Chen, T., You, Y., Jiang, H. & Wang, Z. Z., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Biological Phenomena
Epithelial-Mesenchymal Transition
Stem cells
Cell Differentiation
Carcinogenesis
megakaryocytes
Induced Pluripotent Stem Cells
Megakaryocytes
Stem cells
transcriptomics
Pluripotent Stem Cells
Cell Aging
Transforming Growth Factors
Endothelial Cells
Blood Vessels
2016

Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells

Bai, H., Liu, Y., Xie, Y., Hoyle, D. L., Brodsky, R. A., Cheng, L., Cheng, T. & Wang, Z. Z., May 1 2016, In : Journal of Cellular Physiology. 231, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Hemangioblasts
Pluripotent Stem Cells
Endothelial cells
Hematopoietic Stem Cells
Stem cells
2015

Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells

Xie, Y., Bai, H., Liu, Y., Hoyle, D. L., Cheng, T. & Wang, Z. Z., Dec 1 2015, In : Journal of Cellular Biochemistry. 116, 12, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Human Development
Erythropoietin
Stem cells
Erythroid Cells

Derivation of megakaryocytes and platelets from human pluripotent stem cells

Li, Y., Wang, Y., Cheng, L. & Wang, Z. Z., Aug 25 2015, Hematopoietic Differentiation of Human Pluripotent Stem Cells. Springer Netherlands, p. 41-50 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pluripotent Stem Cells
Megakaryocytes
Platelets
Stem cells
Blood Platelets

Development of hematopoietic stem and progenitor cells from human pluripotent stem cells

Chen, T., Wang, F., Wu, M. & Wang, Z. Z., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. V

Research output: Contribution to journalArticle

Signal transduction
Stem cells
Endothelial cells
Blood
Medicine

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents

Liu, Y., Wang, Y., Wang, Y., Wang, Y., Gao, Y., Gao, Y., Forbes, J. A., Qayyum, R., Becker, L., Cheng, L., Cheng, L., Wang, Z. Z. & Wang, Z. Z., 2015, In : Stem cells translational medicine. 4, 4, p. 309-319 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Megakaryocytes
United States Food and Drug Administration
Pharmacology
oprelvekin

EphB4 Forward-Signaling Regulates Cardiac Progenitor Development in Mouse ES Cells

Chen, K., Bai, H., Liu, Y., Hoyle, D. L., Shen, W. F., Wu, L. Q. & Wang, Z. Z., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 467-475 9 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Stem Cells
EphA1 Receptor
2014

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks

Dowell, K. G., Simons, A. K., Bai, H., Kell, B., Wang, Z. Z., Yun, K. & Hibbs, M. A., 2014, In : Stem Cells. 32, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Systems Biology
Embryonic Stem Cells
Genes
Leukemia Inhibitory Factor
Developmental Biology

Priming of Toll-like receptor 4 pathway in mesenchymal stem cells increases expression of B cell activating factor

Yan, H., Wu, M., Yuan, Y., Wang, Z. Z., Jiang, H. & Chen, T., May 30 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 212-217 6 p.

Research output: Contribution to journalArticle

B-Cell Activating Factor
Toll-Like Receptor 4
Stem cells
Mesenchymal Stromal Cells
Toll-Like Receptors
2013

Cell-Type-Specific Predictive Network Yields Novel Insights into Mouse Embryonic Stem Cell Self-Renewal and Cell Fate

Dowell, K. G., Simons, A. K., Wang, Z. Z., Yun, K. & Hibbs, M. A., Feb 28 2013, In : PLoS One. 8, 2, e56810.

Research output: Contribution to journalArticle

embryonic stem cells
Stem cells
stem cells
Stem Cells
Biological Phenomena

Corrigendum to "Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal" [Stem Cell Res. 8 (2012) 26-37]

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Nov 2013, In : Stem Cell Research. 11, 3, p. 1272 1 p.

Research output: Contribution to journalArticle

Cell Survival
Human Embryonic Stem Cells
corrigendum
Cell Self Renewal

Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis

Tang, Y., Bai, H., Urs, S., Wang, Z. Z. & Liaw, L., 2013, In : Transgenic Research. 22, 2, p. 403-410 8 p.

Research output: Contribution to journalArticle

hematopoiesis
cadherins
Hematopoiesis
Hematopoietic Stem Cells
Mesonephros

The balance of positive and negative effects of TGF-β signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells

Bai, H., Xie, Y. L., Gao, Y. X., Cheng, T. & Wang, Z. Z., Oct 15 2013, In : Stem Cells and Development. 22, 20, p. 2765-2776 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Transforming Growth Factor beta
Mesoderm
Hemangioblasts
Cell Differentiation
2012

Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal

Bai, H., Chen, K., Gao, Y. X., Arzigian, M., Xie, Y. L., Malcosky, C., Yang, Y. G., Wu, W. S. & Wang, Z. Z., Jan 2012, In : Stem Cell Research. 8, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Cell Survival
Apoptosis
Human Embryonic Stem Cells
Embryoid Bodies
Gene Expression

Stem cell science on the rise in China

Yuan, W., Sipp, D., Wang, Z. Z., Deng, H., Pei, D., Zhou, Q. & Cheng, T., Jan 6 2012, In : Cell Stem Cell. 10, 1, p. 12-15 4 p.

Research output: Contribution to journalArticle

Clinical Governance
Stem Cell Research
China
Stem Cells
Growth
2011

2010 International Forum on Stem Cells (November 11-13; Tianjin, China)

Sipp, D., Wang, Z. Z. & Yuan, W., Sep 2011, In : Stem Cell Reviews and Reports. 7, 3, p. 479-481 3 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Biomedical Research
China
Stem Cells

Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds

Zhang, Z., Gao, Y., Gordon, A., Wang, Z. Z., Qian, Z. & Wu, W. S., 2011, In : PLoS One. 6, 10, e26592.

Research output: Contribution to journalArticle

retroviral vectors
Induced Pluripotent Stem Cells
Chemical compounds
chemical compounds
Stem cells

F-box protein 10, an NF-B-κdependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway

Ge, R., Wang, Z. Z., Zeng, Q., Xu, X. & Olumi, A. F., Jul 2011, In : Cell Death and Differentiation. 18, 7, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

F-Box Proteins
Apoptosis Regulatory Proteins
Apoptosis
Transcription Factor AP-1
Neoplasms
2010

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

Kuang, S. Q., Bai, H., Fang, Z. H., Lopez, G., Yang, H., Tong, W., Wang, Z. Z. & Garcia-Manero, G., Mar 25 2010, In : Blood. 115, 12, p. 2412-2419 8 p.

Research output: Contribution to journalArticle

Eph Family Receptors
Ephrins
DNA Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epigenomics

BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway

Bai, H., Gao, Y., Arzigian, M., Wojchowski, D. M., Wu, W. S. & Wang, Z. Z., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

Stem cells
Blood Vessels
Cell Differentiation
Muscle
Cells

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Shao, L., Sun, Y., Zhang, Z., Feng, W., Gao, Y., Cai, Z., Wang, Z. Z., Look, A. T. & Wu, W. S., Jun 10 2010, In : Blood. 115, 23, p. 4707-4714 8 p.

Research output: Contribution to journalArticle

Puma
Hematopoietic Stem Cells
Stem cells
Dosimetry
Radiation

Endothelial cells regulate cardiomyocyte development from embryonic stem cells

Chen, K., Bai, H., Arzigian, M., Gao, Y. X., Bao, J., Wu, W. S., Shen, W. F., Wu, L. & Wang, Z. Z., Sep 1 2010, In : Journal of Cellular Biochemistry. 111, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Endothelial cells
Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Endothelial Cells

Hemato-endothelial differentiation from lentiviral-transduced human embryonic stem cells retains durable reporter gene expression under the control of ubiquitin promoter

Jiang, H., Lin, X., Feng, Y., Xie, Y., Han, J., Zhang, Y., Wang, Z. Z. & Chen, T., Jan 2010, In : Cytotechnology. 62, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Ubiquitin
Stem cells
Reporter Genes
Gene expression
Gene Expression

Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration

Sun, Y., Shao, L., Bai, H., Wang, Z. Z. & Wu, W. S., Mar 4 2010, In : Blood. 115, 9, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

Gastropoda
Hematopoietic Stem Cells
Stem cells
Regeneration
Transcription Factors
2009

Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame

Shao, L., Feng, W., Sun, Y., Bai, H., Liu, J., Currie, C., Kim, J., Gama, R., Wang, Z. Z., Qian, Z., Liaw, L. & Wu, W. S., Mar 2009, In : Cell Research. 19, 3, p. 296-306 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Open Reading Frames
Transgenes
Transcription Factors
Virus Integration

Hematopoietic SCT in patients with a history of invasive fungal infection

Zhang, P., Song, A., Wang, Z. Z., Feng, S., Qiu, L. & Han, M., 2009, In : Bone Marrow Transplantation. 43, 7, p. 533-537 5 p.

Research output: Contribution to journalArticle

Antifungal Agents
Transplantation
Invasive Fungal Infections
Infection
Adrenal Cortex Hormones
2008

Directing human embryonic stem cells to generate vascular progenitor cells

Bai, H. & Wang, Z. Z., Jan 2008, In : Gene Therapy. 15, 2, p. 89-95 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Stem Cells
Smooth Muscle Myocytes
Endothelial Cells
Vascular Diseases

Establishment of sprouting embryoid body model mimicking early embryonic vasculogenesis in human embryo

Jiang, H., Feng, Y. J., Xie, Y., Han, J. L., Wang, Z. Z. & Chen, T., Oct 14 2008, In : Zhonghua yi xue za zhi. 88, 37, p. 2647-2651 5 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Fibroblast Growth Factors
Vascular Endothelial Growth Factor A
Embryonic Structures
Angiostatins

Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells

Chen, K., Wu, L. & Wang, Z. Z., May 1 2008, In : Journal of Cellular Biochemistry. 104, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Tissue
Muscle

Mechanisms that mediate stem cell self-renewal and differentiation

Zhang, H. & Wang, Z. Z., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 709-718 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Stem Cells
Adult Stem Cells
Neoplastic Stem Cells
2007

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Wang, Z. Z., Au, P., Chen, T., Shao, Y., Daheron, L. M., Bai, H., Arzigian, M., Fukumura, D., Jain, R. K. & Scadden, D. T., Mar 2007, In : Nature Biotechnology. 25, 3, p. 317-318 2 p.

Research output: Contribution to journalArticle

Embryoid Bodies
SCID Mice
Endothelial cells
Blood vessels
Cardiovascular System

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro

Chen, T., Bai, H., Shao, Y., Arzigian, M., Janzen, V., Attar, E., Xie, Y., Scadden, D. T. & Wang, Z. Z., Feb 2007, In : Stem Cells. 25, 2, p. 392-401 10 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Endothelium
Organizations
Blood Vessels
Embryoid Bodies
2005

Expression of alternatively spliced isoforms of platelet endothelial cell adhesion molecule-1 of embryonic stem cells during vasculogenesis and angiogenesis

Li, Z. J., Xu, B., Li, Y. H., Lu, S. H., Zheng, Y. Z., Yang, R. C., Wang, Z. Z., Qian, G. Q. & Han, Z. C., May 25 2005, In : Zhonghua yi xue za zhi. 85, 19, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

CD31 Antigens
Embryonic Stem Cells
Protein Isoforms
Exons
CD15 Antigens

In vitro vasculogenesis and angiogenesis of mouse embryonic stem cells

Li, Z. J., Yang, C., Tang, F. W., Zhang, Z. H., Xu, B., Zhao, Q. J., Yang, R. C., Wang, Z. Z. & Han, Z. C., Feb 2005, In : Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.. 27, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

Embryoid Bodies
CD31 Antigens
Smooth Muscle
Blood Vessels
Endothelial Cells

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation

Li, Z. J., Wang, Z. Z., Zheng, Y. Z., Xu, B., Yang, R. C., Scadden, D. T. & Han, Z. C., Jun 1 2005, In : Journal of Cellular Biochemistry. 95, 3, p. 559-570 12 p.

Research output: Contribution to journalArticle

CD31 Antigens
Embryonic Stem Cells
Stem cells
Cell Differentiation
Kinetics
2004

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels

Wang, Z. Z., Cohen, K., Shao, Y., Mole, P., Dombkowski, D. & Scadden, D. T., Jan 1 2004, In : Blood. 103, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

Hemangioblasts
Eph Family Receptors
Blood vessels
Embryonic Stem Cells
Stem cells
2002

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells

Wang, Z. Z., Miura, N., Bonelli, A., Mole, P., Carlesso, N., Olson, D. P. & Scadden, D. T., Apr 15 2002, In : Blood. 99, 8, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Bone
Cells
Ligands
Genistein

Signaling by the Mpl receptor involves IKK and NF-κB

Zhang, Y., Sun, S., Wang, Z. Z., Thompson, A., Kaluzhny, Y., Zimmet, J. & Ravid, K., 2002, In : Journal of Cellular Biochemistry. 85, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

Thrombopoietin
Megakaryocytes
Cells
Apoptosis
DNA

Thymocyte emigration is mediated by active movement away from stroma-derived factors

Poznansky, M. C., Olszak, I. T., Evans, R. H., Wang, Z. Z., Foxall, R. B., Olson, D. P., Weibrecht, K., Luster, A. D. & Scadden, D. T., 2002, In : Journal of Clinical Investigation. 109, 8, p. 1101-1110 10 p.

Research output: Contribution to journalArticle

Emigration and Immigration
Thymocytes
Thymus Gland
T-Lymphocytes
Chemokine CXCL12
2000

The impact of hepatitis B virus infected patients or donors on the outcome of hematopoietic stem cell transplantation

Feng, S., Han, M., Zhang, L., Li, C., Qiu, L., Li, H., Wang, Z. Z., Jiang, R., Yan, W. & Han, Z., 2000, In : Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 21, 8, p. 414-416 3 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Hepatitis B virus
Tissue Donors
Liver Failure
Hepatitis B

The receptor tyrosine kinase, EphB4 (HTK), promotes megakaryocytic and erythroid differentiation

Wang, Z. Z., Miura, N., Bonelli, A., Mole, P. & Scadden, D. T., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Cells
Fetal Blood
Cell Line
Blood Cells
1999

Mpl ligand enhances the transcription of the cyclin D3 gene: A potential role for Sp1 transcription factor

Wang, Z. Z., Zhang, Y., Lu, J., Sun, S. & Ravid, K., Jun 15 1999, In : Blood. 93, 12, p. 4208-4221 14 p.

Research output: Contribution to journalArticle

Cyclin D3
Sp1 Transcription Factor
Thrombopoietin
Transcription
Genes
1998

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes

Zhang, Y., Wang, Z. Z., Liu, D. X., Pagano, M. & Ravid, K., Jan 16 1998, In : Journal of Biological Chemistry. 273, 3, p. 1387-1392 6 p.

Research output: Contribution to journalArticle

Cyclin B
Cyclin B1
Polyploidy
Megakaryocytes
Ubiquitin
1996

Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity

Wang, Z. Z., Sicinski, P., Weinberg, R. A., Zhang, Y. & Ravid, K., Jul 1 1996, In : Genomics. 35, 1, p. 156-163 8 p.

Research output: Contribution to journalArticle

Cyclin D3
Introns
Exons
Cyclins
Transcription Initiation Site

The cell cycle in polyploid megakaryoeytes is associated with reduced activity of cyclin B1-dependent Cdc2 kinase

Zhang, Y., Wang, Z. Z. & Ravid, K., Feb 23 1996, In : Journal of Biological Chemistry. 271, 8, p. 4266-4272 7 p.

Research output: Contribution to journalArticle

Cyclin B1
Polyploidy
Cell Cycle
Phosphotransferases
Megakaryocytes
1995

Cyclin D3 is essential for megakaryocytopoiesis

Wang, Z. Z., Zhang, Y., Kamen, D., Lees, E. & Ravid, K., 1995, In : Blood. 86, 10, p. 3783-3788 6 p.

Research output: Contribution to journalArticle

Cyclin D3
Thrombopoiesis
Megakaryocytes
Cyclin B1
Cyclins